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Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor.
Kanada R, Kagoshima Y, Suzuki T, Nakamura A, Funami H, Watanabe J, Asano M, Takahashi M, Ubukata O, Suzuki K, Aikawa T, Sato K, Goto M, Setsu G, Ito K, Kihara K, Kuroha M, Kohno T, Ogiwara H, Isoyama T, Tominaga Y, Higuchi S, Naito H. Kanada R, et al. Among authors: suzuki k, suzuki t. J Med Chem. 2023 Jan 12;66(1):695-715. doi: 10.1021/acs.jmedchem.2c01641. Epub 2022 Dec 26. J Med Chem. 2023. PMID: 36572866
Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring.
Kanada R, Kagoshima Y, Asano M, Suzuki T, Murata T, Haruta M, Takahashi M, Ubukata O, Hashimoto K, Obata K, Kihara K, Kuroha M, Banjo T, Togashi N, Sato K, Yamamoto Y, Suzuki K, Isoyama T, Tominaga Y, Higuchi S, Naito H. Kanada R, et al. Among authors: suzuki k, suzuki t. Bioorg Med Chem Lett. 2022 Jun 15;66:128726. doi: 10.1016/j.bmcl.2022.128726. Epub 2022 Apr 9. Bioorg Med Chem Lett. 2022. PMID: 35413416
DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model.
Jimbo T, Hatanaka M, Komatsu T, Taira T, Kumazawa K, Maeda N, Suzuki T, Ota M, Haginoya N, Isoyama T, Fujiwara K. Jimbo T, et al. Among authors: suzuki t. Oncotarget. 2019 Aug 27;10(50):5152-5167. doi: 10.18632/oncotarget.27114. eCollection 2019 Aug 27. Oncotarget. 2019. PMID: 31497246 Free PMC article.
Muraminomicins, new lipo-nucleoside antibiotics from Streptosporangium sp. SANK 60501-structure elucidations of muraminomicins and supply of the core component for derivatization.
Fujita Y, Kagoshima Y, Masuda T, Kizuka M, Ogawa Y, Endo S, Nishigoori H, Saito K, Takasugi K, Miura M, Murakami R, Muramatsu Y, Tokumitsu A, Koga T, Iizuka M, Aoyagi A, Suzuki T, Suzuki T, Suzuki Y, Ishida O, Nakahira T, Miyakoshi S, Konosu T, Takatsu T. Fujita Y, et al. Among authors: suzuki y, suzuki t. J Antibiot (Tokyo). 2019 Dec;72(12):943-955. doi: 10.1038/s41429-019-0215-7. Epub 2019 Aug 14. J Antibiot (Tokyo). 2019. PMID: 31413314
A novel assay of bacterial peptidoglycan synthesis for natural product screening.
Murakami R, Muramatsu Y, Minami E, Masuda K, Sakaida Y, Endo S, Suzuki T, Ishida O, Takatsu T, Miyakoshi S, Inukai M, Isono F. Murakami R, et al. Among authors: suzuki t. J Antibiot (Tokyo). 2009 Mar;62(3):153-8. doi: 10.1038/ja.2009.4. Epub 2009 Feb 20. J Antibiot (Tokyo). 2009. PMID: 19229285
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