Surmiak E - Search Results

1

NMR fragment-based screening for development of the CD44-binding small molecules.

Pustuła M, Czub M, Łabuzek B, Surmiak E, Tomala M, Twarda-Clapa A, Guzik K, Popowicz GM, Holak TA. Pustuła M, et al. Among authors: surmiak e. Bioorg Chem. 2019 Feb;82:284-289. doi: 10.1016/j.bioorg.2018.10.043. Epub 2018 Oct 25. Bioorg Chem. 2019. PMID: 30396062

2

A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.

Surmiak E, Twarda-Clapa A, Zak KM, Musielak B, Tomala MD, Kubica K, Grudnik P, Madej M, Jablonski M, Potempa J, Kalinowska-Tluscik J, Dömling A, Dubin G, Holak TA. Surmiak E, et al. ACS Chem Biol. 2016 Dec 16;11(12):3310-3318. doi: 10.1021/acschembio.6b00596. Epub 2016 Oct 17. ACS Chem Biol. 2016. PMID: 27709883

3

Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction.

Surmiak E, Neochoritis CG, Musielak B, Twarda-Clapa A, Kurpiewska K, Dubin G, Camacho C, Holak TA, Dömling A. Surmiak E, et al. Eur J Med Chem. 2017 Jan 27;126:384-407. doi: 10.1016/j.ejmech.2016.11.029. Epub 2016 Nov 16. Eur J Med Chem. 2017. PMID: 27907876

4

A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53^wt osteosarcoma cells.

Skalniak L, Twarda-Clapa A, Neochoritis CG, Surmiak E, Machula M, Wisniewska A, Labuzek B, Ali AM, Krzanik S, Dubin G, Groves M, Dömling A, Holak TA. Skalniak L, et al. Among authors: surmiak e. FEBS J. 2019 Apr;286(7):1360-1374. doi: 10.1111/febs.14774. Epub 2019 Feb 16. FEBS J. 2019. PMID: 30715803 Free PMC article.

5

A therapeutic patent overview of MDM2/X-targeted therapies (2014-2018).

Skalniak L, Surmiak E, Holak TA. Skalniak L, et al. Among authors: surmiak e. Expert Opin Ther Pat. 2019 Mar;29(3):151-170. doi: 10.1080/13543776.2019.1582645. Epub 2019 Mar 1. Expert Opin Ther Pat. 2019. PMID: 30822185 Review.

6

Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists.

Neochoritis CG, Kazemi Miraki M, Abdelraheem EMM, Surmiak E, Zarganes-Tzitzikas T, Łabuzek B, Holak TA, Dömling A. Neochoritis CG, et al. Among authors: surmiak e. Beilstein J Org Chem. 2019 Feb 20;15:513-520. doi: 10.3762/bjoc.15.45. eCollection 2019. Beilstein J Org Chem. 2019. PMID: 30873235 Free PMC article.

7

Helping the Released Guardian: Drug Combinations for Supporting the Anticancer Activity of HDM2 (MDM2) Antagonists.

Kocik J, Machula M, Wisniewska A, Surmiak E, Holak TA, Skalniak L. Kocik J, et al. Among authors: surmiak e. Cancers (Basel). 2019 Jul 19;11(7):1014. doi: 10.3390/cancers11071014. Cancers (Basel). 2019. PMID: 31331108 Free PMC article. Review.

8

Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction.

Neochoritis CG, Atmaj J, Twarda-Clapa A, Surmiak E, Skalniak L, Köhler LM, Muszak D, Kurpiewska K, Kalinowska-Tłuścik J, Beck B, Holak TA, Dömling A. Neochoritis CG, et al. Among authors: surmiak e. Eur J Med Chem. 2019 Nov 15;182:111588. doi: 10.1016/j.ejmech.2019.111588. Epub 2019 Aug 6. Eur J Med Chem. 2019. PMID: 31421630 Free PMC article.

9

Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions.

Ricardo MG, Ali AM, Plewka J, Surmiak E, Labuzek B, Neochoritis CG, Atmaj J, Skalniak L, Zhang R, Holak TA, Groves M, Rivera DG, Dömling A. Ricardo MG, et al. Among authors: surmiak e. Angew Chem Int Ed Engl. 2020 Mar 23;59(13):5235-5241. doi: 10.1002/anie.201916257. Epub 2020 Feb 6. Angew Chem Int Ed Engl. 2020. PMID: 31944488

10

Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists.

Butera R, Ważyńska M, Magiera-Mularz K, Plewka J, Musielak B, Surmiak E, Sala D, Kitel R, de Bruyn M, Nijman HW, Elsinga PH, Holak TA, Dömling A. Butera R, et al. Among authors: surmiak e. ACS Med Chem Lett. 2021 Apr 28;12(5):768-773. doi: 10.1021/acsmedchemlett.1c00033. eCollection 2021 May 13. ACS Med Chem Lett. 2021. PMID: 34055224 Free PMC article.

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