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A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits.
Anil TM, Dandu A, Harsha K, Singh J, Shree N, Kumar VS, Lakshmi MN, Sunil V, Harish C, Balamurali GV, Naveen Kumar BS, Gopala AS, Pratibha S, Sadasivuni M, Anup MO, Moolemath Y, Venkataranganna MV, Jagannath MR, Somesh BP. Anil TM, et al. Among authors: sunil v. BMC Pharmacol Toxicol. 2014 Aug 7;15:43. doi: 10.1186/2050-6511-15-43. BMC Pharmacol Toxicol. 2014. PMID: 25098735 Free PMC article.
Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats.
Gowda N, Dandu A, Singh J, Biswas S, Raghav V, Lakshmi MN, Shilpa PC, Sunil V, Reddy A, Sadasivuni M, Aparna K, Verma MK, Moolemath Y, Anup MO, Venkataranganna MV, Somesh BP, Jagannath MR. Gowda N, et al. Among authors: sunil v. BMC Pharmacol Toxicol. 2013 May 21;14:28. doi: 10.1186/2050-6511-14-28. BMC Pharmacol Toxicol. 2013. PMID: 23692921 Free PMC article.
CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients.
Sunil V, Verma MK, Oommen AM, Sadasivuni M, Singh J, Vijayraghav DN, Chandravanshi B, Shetty J, Biswas S, Dandu A, Moolemath Y, Venkataranganna MV, Somesh BP, Jagannath MR. Sunil V, et al. BMC Pharmacol Toxicol. 2014 Mar 25;15:19. doi: 10.1186/2050-6511-15-19. BMC Pharmacol Toxicol. 2014. PMID: 24666736 Free PMC article.
CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models.
Sadasivuni MK, Reddy BM, Singh J, Anup MO, Sunil V, Lakshmi MN, Yogeshwari S, Chacko SK, Pooja TL, Dandu A, Harish C, Gopala AS, Pratibha S, Naveenkumar BS, Pallavi PM, Verma MK, Moolemath Y, Somesh BP, Venkataranganna MV, Jagannath MR. Sadasivuni MK, et al. Among authors: sunil v. Diabetol Metab Syndr. 2014 Aug 12;6(1):83. doi: 10.1186/1758-5996-6-83. eCollection 2014. Diabetol Metab Syndr. 2014. PMID: 25143786 Free PMC article.
Prevalence of Psychiatric Morbidity and Alcohol use Disorders Among Adolescent Indigenous Tribals from Three Indian States.
Gharat VV, Chandramouleeshwaran S, Nayak S, War RJ, Deshpande SN, Nimgaonkar VL, Shah HM, Patel RR, Kyndiah MD, Shylla WED, Sunil V, Mohanraj S, Devi MD, Shukla K, Devi S. Gharat VV, et al. Among authors: sunil v. Indian J Psychol Med. 2024 Jan;46(1):39-45. doi: 10.1177/02537176231196290. Epub 2023 Oct 2. Indian J Psychol Med. 2024. PMID: 38524954 Free PMC article.
Role of macrophage bioenergetics in N-acetylcysteine-mediated mitigation of lung injury and oxidative stress induced by nitrogen mustard.
Malaviya R, Meshanni JA, Sunil VR, Venosa A, Guo C, Abramova EV, Vayas KN, Jiang C, Cervelli JA, Gow AJ, Laskin JD, Laskin DL. Malaviya R, et al. Among authors: sunil vr. Toxicol Appl Pharmacol. 2024 Apr;485:116908. doi: 10.1016/j.taap.2024.116908. Epub 2024 Mar 19. Toxicol Appl Pharmacol. 2024. PMID: 38513841 Free article.
67 results