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Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling.
Sun Z, Liu Q, Lv Z, Li J, Xu X, Sun H, Wang M, Sun K, Shi T, Liu Z, Tan G, Yan W, Wu R, Yang YX, Ikegawa S, Jiang Q, Sun Y, Shi D. Sun Z, et al. Among authors: sun k, sun y, sun h. Acta Pharm Sin B. 2022 Jul;12(7):3073-3084. doi: 10.1016/j.apsb.2022.02.010. Epub 2022 Feb 17. Acta Pharm Sin B. 2022. PMID: 35865095 Free PMC article.
SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade.
Zhao M, Guo W, Wu Y, Yang C, Zhong L, Deng G, Zhu Y, Liu W, Gu Y, Lu Y, Kong L, Meng X, Xu Q, Sun Y. Zhao M, et al. Among authors: sun y. Acta Pharm Sin B. 2019 Mar;9(2):304-315. doi: 10.1016/j.apsb.2018.08.009. Epub 2018 Sep 5. Acta Pharm Sin B. 2019. PMID: 30972278 Free PMC article.
Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies.
Song Z, Wang M, Ge Y, Chen XP, Xu Z, Sun Y, Xiong XF. Song Z, et al. Among authors: sun y. Acta Pharm Sin B. 2021 Jan;11(1):13-29. doi: 10.1016/j.apsb.2020.07.010. Epub 2020 Jul 26. Acta Pharm Sin B. 2021. PMID: 33532178 Free PMC article. Review.
SH2 Domain-Containing Phosphatase 2 Inhibition Attenuates Osteoarthritis by Maintaining Homeostasis of Cartilage Metabolism via the Docking Protein 1/Uridine Phosphorylase 1/Uridine Cascade.
Liu Q, Zhai L, Han M, Shi D, Sun Z, Peng S, Wang M, Zhang C, Gao J, Yan W, Jiang Q, Chen D, Xu Q, Tan M, Sun Y. Liu Q, et al. Among authors: sun z, sun y. Arthritis Rheumatol. 2022 Mar;74(3):462-474. doi: 10.1002/art.41988. Epub 2022 Feb 2. Arthritis Rheumatol. 2022. PMID: 34569725
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