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CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.
Pluvinage JV, Haney MS, Smith BAH, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Yang AC, Shuken SR, Gate D, Scott M, Khatri P, Luo J, Bertozzi CR, Bassik MC, Wyss-Coray T. Pluvinage JV, et al. Among authors: sun j. Nature. 2019 Apr;568(7751):187-192. doi: 10.1038/s41586-019-1088-4. Epub 2019 Apr 3. Nature. 2019. PMID: 30944478 Free PMC article.
The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C.
Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pașca AM, Pașca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T. Pluvinage JV, et al. Among authors: sun j. Sci Transl Med. 2021 Dec;13(622):eabg2919. doi: 10.1126/scitranslmed.abg2919. Epub 2021 Dec 1. Sci Transl Med. 2021. PMID: 34851695 Free PMC article.
Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release.
Tufan T, Comertpay G, Villani A, Nelson GM, Terekhova M, Kelley S, Zakharov P, Ellison RM, Shpynov O, Raymond M, Sun J, Chen Y, Bockelmann E, Stremska M, Peterson LW, Boeckaerts L, Goldman SR, Etchegaray JI, Artyomov MN, Peri F, Ravichandran KS. Tufan T, et al. Among authors: sun j. Nature. 2024 Apr;628(8007):408-415. doi: 10.1038/s41586-024-07172-y. Epub 2024 Mar 13. Nature. 2024. PMID: 38480883
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