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Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells.
Oh MH, Sun IH, Zhao L, Leone RD, Sun IM, Xu W, Collins SL, Tam AJ, Blosser RL, Patel CH, Englert JM, Arwood ML, Wen J, Chan-Li Y, Tenora L, Majer P, Rais R, Slusher BS, Horton MR, Powell JD. Oh MH, et al. Among authors: sun ih, sun im. J Clin Invest. 2020 Jul 1;130(7):3865-3884. doi: 10.1172/JCI131859. J Clin Invest. 2020. PMID: 32324593 Free PMC article.
Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models.
Leone RD, Sun IM, Oh MH, Sun IH, Wen J, Englert J, Powell JD. Leone RD, et al. Among authors: sun ih, sun im. Cancer Immunol Immunother. 2018 Aug;67(8):1271-1284. doi: 10.1007/s00262-018-2186-0. Epub 2018 Jun 19. Cancer Immunol Immunother. 2018. PMID: 29923026 Free PMC article.
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.
Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, Tam A, Blosser RL, Prchalova E, Alt J, Rais R, Slusher BS, Powell JD. Leone RD, et al. Among authors: sun ih, sun im. Science. 2019 Nov 22;366(6468):1013-1021. doi: 10.1126/science.aav2588. Epub 2019 Nov 7. Science. 2019. PMID: 31699883 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 36332975
GOT1 regulates CD8+ effector and memory T cell generation.
Xu W, Patel CH, Zhao L, Sun IH, Oh MH, Sun IM, Helms RS, Wen J, Powell JD. Xu W, et al. Among authors: sun ih, sun im. Cell Rep. 2023 Jan 31;42(1):111987. doi: 10.1016/j.celrep.2022.111987. Epub 2023 Jan 12. Cell Rep. 2023. PMID: 36640309 Free PMC article.
Serendipitous Discovery of T Cell-Produced KLK1b22 as a Regulator of Systemic Metabolism.
Arwood ML, Sun IH, Patel CH, Sun IM, Oh MH, Bettencourt IA, Claiborne MD, Chan-Li Y, Zhao L, Waickman AT, Mavrothalassitis O, Wen J, Aja S, Powell JD. Arwood ML, et al. Among authors: sun ih, sun im. Immunohorizons. 2023 Jun 1;7(6):493-507. doi: 10.4049/immunohorizons.2300016. Immunohorizons. 2023. PMID: 37358498 Free PMC article.
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.
Baumgartner CK, Ebrahimi-Nik H, Iracheta-Vellve A, Hamel KM, Olander KE, Davis TGR, McGuire KA, Halvorsen GT, Avila OI, Patel CH, Kim SY, Kammula AV, Muscato AJ, Halliwill K, Geda P, Klinge KL, Xiong Z, Duggan R, Mu L, Yeary MD, Patti JC, Balon TM, Mathew R, Backus C, Kennedy DE, Chen A, Longenecker K, Klahn JT, Hrusch CL, Krishnan N, Hutchins CW, Dunning JP, Bulic M, Tiwari P, Colvin KJ, Chuong CL, Kohnle IC, Rees MG, Boghossian A, Ronan M, Roth JA, Wu MJ, Suermondt JSMT, Knudsen NH, Cheruiyot CK, Sen DR, Griffin GK, Golub TR, El-Bardeesy N, Decker JH, Yang Y, Guffroy M, Fossey S, Trusk P, Sun IM, Liu Y, Qiu W, Sun Q, Paddock MN, Farney EP, Matulenko MA, Beauregard C, Frost JM, Yates KB, Kym PR, Manguso RT. Baumgartner CK, et al. Among authors: sun im. Nature. 2023 Oct;622(7984):850-862. doi: 10.1038/s41586-023-06575-7. Epub 2023 Oct 4. Nature. 2023. PMID: 37794185 Free PMC article.
112 results