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Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.
Tsukada A, Suemizu H, Murayama N, Takano R, Shimizu M, Nakamura M, Yamazaki H. Tsukada A, et al. Among authors: suemizu h. Regul Toxicol Pharmacol. 2013 Apr;65(3):316-24. doi: 10.1016/j.yrtph.2013.01.008. Epub 2013 Feb 5. Regul Toxicol Pharmacol. 2013. PMID: 23395687
Novel metastasis models of human cancer in NOG mice.
Nakamura M, Suemizu H. Nakamura M, et al. Among authors: suemizu h. Curr Top Microbiol Immunol. 2008;324:167-77. doi: 10.1007/978-3-540-75647-7_11. Curr Top Microbiol Immunol. 2008. PMID: 18481460 Review.
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.
Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnai M, Wakui M, Ito M, Suematsu M, Peltz G, Nakamura M, Suemizu H. Hasegawa M, et al. Among authors: suemizu h. Biochem Biophys Res Commun. 2011 Feb 18;405(3):405-10. doi: 10.1016/j.bbrc.2011.01.042. Epub 2011 Jan 14. Biochem Biophys Res Commun. 2011. PMID: 21238430 Free PMC article.
195 results