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Treatment of exudative age-related macular degeneration with a designed ankyrin repeat protein that binds vascular endothelial growth factor: a phase I/II study.
Souied EH, Devin F, Mauget-Faÿsse M, Kolář P, Wolf-Schnurrbusch U, Framme C, Gaucher D, Querques G, Stumpp MT, Wolf S; MP0112 Study Group. Souied EH, et al. Among authors: stumpp mt. Am J Ophthalmol. 2014 Oct;158(4):724-732.e2. doi: 10.1016/j.ajo.2014.05.037. Epub 2014 Jun 5. Am J Ophthalmol. 2014. PMID: 24907435 Free article. Clinical Trial.
First-in-Human Phase I Study of MP0250, a First-in-Class DARPin Drug Candidate Targeting VEGF and HGF, in Patients With Advanced Solid Tumors.
Baird RD, Linossi C, Middleton M, Lord S, Harris A, Rodón J, Zitt C, Fiedler U, Dawson KM, Leupin N, Stumpp MT, Harstrick A, Azaro A, Fischer S, Omlin A. Baird RD, et al. Among authors: stumpp mt. J Clin Oncol. 2021 Jan 10;39(2):145-154. doi: 10.1200/JCO.20.00596. Epub 2020 Dec 10. J Clin Oncol. 2021. PMID: 33301375 Free PMC article. Clinical Trial.
DARPins: a new generation of protein therapeutics.
Stumpp MT, Binz HK, Amstutz P. Stumpp MT, et al. Drug Discov Today. 2008 Aug;13(15-16):695-701. doi: 10.1016/j.drudis.2008.04.013. Epub 2008 Jul 11. Drug Discov Today. 2008. PMID: 18621567 Review.
Half-life extension using serum albumin-binding DARPin® domains.
Steiner D, Merz FW, Sonderegger I, Gulotti-Georgieva M, Villemagne D, Phillips DJ, Forrer P, Stumpp MT, Zitt C, Binz HK. Steiner D, et al. Among authors: stumpp mt. Protein Eng Des Sel. 2017 Sep 1;30(9):583-591. doi: 10.1093/protein/gzx022. Protein Eng Des Sel. 2017. PMID: 29088432
Folding of a designed simple ankyrin repeat protein.
Devi VS, Binz HK, Stumpp MT, Plückthun A, Bosshard HR, Jelesarov I. Devi VS, et al. Protein Sci. 2004 Nov;13(11):2864-70. doi: 10.1110/ps.04935704. Protein Sci. 2004. PMID: 15498935 Free PMC article.
Beyond Antibodies: The DARPin® Drug Platform.
Stumpp MT, Dawson KM, Binz HK. Stumpp MT, et al. BioDrugs. 2020 Aug;34(4):423-433. doi: 10.1007/s40259-020-00429-8. BioDrugs. 2020. PMID: 32583318 Free PMC article. Review.
60 results