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Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes.
Solvay M, Holfelder P, Klaessens S, Pilotte L, Stroobant V, Lamy J, Naulaerts S, Spillier Q, Frédérick R, De Plaen E, Sers C, Opitz CA, Van den Eynde BJ, Zhu J. Solvay M, et al. Among authors: stroobant v. J Immunother Cancer. 2023 Jun;11(6):e006728. doi: 10.1136/jitc-2023-006728. J Immunother Cancer. 2023. PMID: 37344101 Free PMC article.
Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase.
Pilotte L, Larrieu P, Stroobant V, Colau D, Dolusic E, Frédérick R, De Plaen E, Uyttenhove C, Wouters J, Masereel B, Van den Eynde BJ. Pilotte L, et al. Among authors: stroobant v. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2497-502. doi: 10.1073/pnas.1113873109. Epub 2012 Jan 30. Proc Natl Acad Sci U S A. 2012. PMID: 22308364 Free PMC article.
Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers.
Hoffmann D, Dvorakova T, Stroobant V, Bouzin C, Daumerie A, Solvay M, Klaessens S, Letellier MC, Renauld JC, van Baren N, Lelotte J, Marbaix E, Van den Eynde BJ. Hoffmann D, et al. Among authors: stroobant v. Cancer Immunol Res. 2020 Jan;8(1):19-31. doi: 10.1158/2326-6066.CIR-19-0040. Epub 2019 Dec 5. Cancer Immunol Res. 2020. PMID: 31806639
Systemic tryptophan homeostasis.
Klaessens S, Stroobant V, De Plaen E, Van den Eynde BJ. Klaessens S, et al. Among authors: stroobant v. Front Mol Biosci. 2022 Sep 14;9:897929. doi: 10.3389/fmolb.2022.897929. eCollection 2022. Front Mol Biosci. 2022. PMID: 36188218 Free PMC article. Review.
107 results