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Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1.
Harrison JS, Cornett EM, Goldfarb D, DaRosa PA, Li ZM, Yan F, Dickson BM, Guo AH, Cantu DV, Kaustov L, Brown PJ, Arrowsmith CH, Erie DA, Major MB, Klevit RE, Krajewski K, Kuhlman B, Strahl BD, Rothbart SB. Harrison JS, et al. Among authors: strahl bd. Elife. 2016 Sep 6;5:e17101. doi: 10.7554/eLife.17101. Elife. 2016. PMID: 27595565 Free PMC article.
Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation.
Ren W, Fan H, Grimm SA, Guo Y, Kim JJ, Yin J, Li L, Petell CJ, Tan XF, Zhang ZM, Coan JP, Gao L, Cai L, Detrick B, Çetin B, Cui Q, Strahl BD, Gozani O, Wang Y, Miller KM, O'Leary SE, Wade PA, Patel DJ, Wang GG, Song J. Ren W, et al. Among authors: strahl bd. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18439-18447. doi: 10.1073/pnas.2009316117. Epub 2020 Jul 16. Proc Natl Acad Sci U S A. 2020. PMID: 32675241 Free PMC article.
Molecular mechanism of the MORC4 ATPase activation.
Tencer AH, Cox KL, Wright GM, Zhang Y, Petell CJ, Klein BJ, Strahl BD, Black JC, Poirier MG, Kutateladze TG. Tencer AH, et al. Among authors: strahl bd. Nat Commun. 2020 Oct 29;11(1):5466. doi: 10.1038/s41467-020-19278-8. Nat Commun. 2020. PMID: 33122719 Free PMC article.
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation.
Ren W, Fan H, Grimm SA, Kim JJ, Li L, Guo Y, Petell CJ, Tan XF, Zhang ZM, Coan JP, Yin J, Kim DI, Gao L, Cai L, Khudaverdyan N, Çetin B, Patel DJ, Wang Y, Cui Q, Strahl BD, Gozani O, Miller KM, O'Leary SE, Wade PA, Wang GG, Song J. Ren W, et al. Among authors: strahl bd. Nat Commun. 2021 May 3;12(1):2490. doi: 10.1038/s41467-021-22665-4. Nat Commun. 2021. PMID: 33941775 Free PMC article.
187 results