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Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.
PLoS One. 2010 Apr 15;5(4):e10186. doi: 10.1371/journal.pone.0010186.
PLoS One. 2010.
PMID: 20419121
Free PMC article.
Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks.
Hawtin RE, Stockett DE, Wong OK, Lundin C, Helleday T, Fox JA.
Hawtin RE, et al. Among authors: stockett de.
Oncotarget. 2010 Nov;1(7):606-619. doi: 10.18632/oncotarget.195.
Oncotarget. 2010.
PMID: 21317456
Free PMC article.
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SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.
Conroy A, Stockett DE, Walker D, Arkin MR, Hoch U, Fox JA, Hawtin RE.
Conroy A, et al. Among authors: stockett de.
Cancer Chemother Pharmacol. 2009 Sep;64(4):723-32. doi: 10.1007/s00280-008-0921-5. Epub 2009 Jan 24.
Cancer Chemother Pharmacol. 2009.
PMID: 19169685
Clinical Trial.
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A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.
Choong IC, Serafimova I, Fan J, Stockett D, Chan E, Cheeti S, Lu Y, Fahr B, Pham P, Arkin MR, Walker DH, Hoch U.
Choong IC, et al.
Bioorg Med Chem Lett. 2008 Nov 1;18(21):5763-5. doi: 10.1016/j.bmcl.2008.09.073. Epub 2008 Sep 24.
Bioorg Med Chem Lett. 2008.
PMID: 18842409
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SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo.
Arbitrario JP, Belmont BJ, Evanchik MJ, Flanagan WM, Fucini RV, Hansen SK, Harris SO, Hashash A, Hoch U, Hogan JN, Howlett AR, Jacobs JW, Lam JW, Ritchie SC, Romanowski MJ, Silverman JA, Stockett DE, Teague JN, Zimmerman KM, Taverna P.
Arbitrario JP, et al. Among authors: stockett de.
Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17. doi: 10.1007/s00280-009-1076-8. Epub 2009 Aug 1.
Cancer Chemother Pharmacol. 2010.
PMID: 19649632
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Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio.
Fan J, Fahr B, Stockett D, Chan E, Cheeti S, Serafimova I, Lu Y, Pham P, Walker DH, Hoch U, Choong IC.
Fan J, et al.
Bioorg Med Chem Lett. 2008 Dec 1;18(23):6236-9. doi: 10.1016/j.bmcl.2008.09.099. Epub 2008 Oct 2.
Bioorg Med Chem Lett. 2008.
PMID: 18926699
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E-selectin up-regulation allows for targeted drug delivery in prostate cancer.
Bhaskar V, Law DA, Ibsen E, Breinberg D, Cass KM, DuBridge RB, Evangelista F, Henshall SM, Hevezi P, Miller JC, Pong M, Powers R, Senter P, Stockett D, Sutherland RL, von Freeden-Jeffry U, Willhite D, Murray R, Afar DE, Ramakrishnan V.
Bhaskar V, et al. Among authors: stockett d.
Cancer Res. 2003 Oct 1;63(19):6387-94.
Cancer Res. 2003.
PMID: 14559828
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