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NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression.
Riedlinger T, Liefke R, Meier-Soelch J, Jurida L, Nist A, Stiewe T, Kracht M, Schmitz ML. Riedlinger T, et al. Among authors: stiewe t. FASEB J. 2019 Mar;33(3):4188-4202. doi: 10.1096/fj.201801638R. Epub 2018 Dec 7. FASEB J. 2019. PMID: 30526044 Free PMC article.
This suggests a mechanism of assisted p65 chromatin association that can be in part facilitated by chromatin priming and cooperativity with other transcription factors such as AP-1.-Riedlinger, T., Liefke, R., Meier-Soelch, J., Jurida, L., Nist, A., Stiewe, T …
This suggests a mechanism of assisted p65 chromatin association that can be in part facilitated by chromatin priming and cooperativity with …
The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state.
Adhikary T, Wortmann A, Schumann T, Finkernagel F, Lieber S, Roth K, Toth PM, Diederich WE, Nist A, Stiewe T, Kleinesudeik L, Reinartz S, Müller-Brüsselbach S, Müller R. Adhikary T, et al. Among authors: stiewe t. Nucleic Acids Res. 2015 May 26;43(10):5033-51. doi: 10.1093/nar/gkv331. Epub 2015 Apr 30. Nucleic Acids Res. 2015. PMID: 25934804 Free PMC article.
Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment.
Schumann T, Adhikary T, Wortmann A, Finkernagel F, Lieber S, Schnitzer E, Legrand N, Schober Y, Nockher WA, Toth PM, Diederich WE, Nist A, Stiewe T, Wagner U, Reinartz S, Müller-Brüsselbach S, Müller R. Schumann T, et al. Among authors: stiewe t. Oncotarget. 2015 May 30;6(15):13416-33. doi: 10.18632/oncotarget.3826. Oncotarget. 2015. PMID: 25968567 Free PMC article.
CRISPR-Cas9-based target validation for p53-reactivating model compounds.
Wanzel M, Vischedyk JB, Gittler MP, Gremke N, Seiz JR, Hefter M, Noack M, Savai R, Mernberger M, Charles JP, Schneikert J, Bretz AC, Nist A, Stiewe T. Wanzel M, et al. Among authors: stiewe t. Nat Chem Biol. 2016 Jan;12(1):22-8. doi: 10.1038/nchembio.1965. Epub 2015 Nov 23. Nat Chem Biol. 2016. PMID: 26595461 Free PMC article.
149 results