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The antiviral effects of a MEK1/2 inhibitor promote tumor regression in a preclinical model of human papillomavirus infection-induced tumorigenesis.
Antiviral Res. 2023 Aug;216:105667. doi: 10.1016/j.antiviral.2023.105667. Epub 2023 Jul 8.
Antiviral Res. 2023.
PMID: 37429527
Free article.
Inhibition of Cellular MEK/ERK Signaling Suppresses Murine Papillomavirus Type 1 Replicative Activities and Promotes Tumor Regression.
Luna AJ, Young JM, Sterk RT, Bondu V, Schultz FA, Kusewitt DF, Kang H, Ozbun MA.
Luna AJ, et al. Among authors: sterk rt.
bioRxiv [Preprint]. 2023 Apr 24:2023.03.14.532042. doi: 10.1101/2023.03.14.532042.
bioRxiv. 2023.
PMID: 36993217
Free PMC article.
Updated.
Preprint.
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Protamine Sulfate Is a Potent Inhibitor of Human Papillomavirus Infection In Vitro and In Vivo.
Young JM, Zine El Abidine A, Gómez-Martinez RA, Bondu V, Sterk RT, Surviladze Z, Ozbun MA.
Young JM, et al. Among authors: sterk rt.
Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0151321. doi: 10.1128/AAC.01513-21. Epub 2021 Nov 1.
Antimicrob Agents Chemother. 2022.
PMID: 34723633
Free PMC article.
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MEK/ERK signaling is a critical regulator of high-risk human papillomavirus oncogene expression revealing therapeutic targets for HPV-induced tumors.
Luna AJ, Sterk RT, Griego-Fisher AM, Chung JY, Berggren KL, Bondu V, Barraza-Flores P, Cowan AT, Gan GN, Yilmaz E, Cho H, Kim JH, Hewitt SM, Bauman JE, Ozbun MA.
Luna AJ, et al. Among authors: sterk rt.
PLoS Pathog. 2021 Jan 22;17(1):e1009216. doi: 10.1371/journal.ppat.1009216. eCollection 2021 Jan.
PLoS Pathog. 2021.
PMID: 33481911
Free PMC article.
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Infectious titres of human papillomaviruses (HPVs) in patient lesions, methodological considerations in evaluating HPV infectivity and implications for the efficacy of high-level disinfectants.
Ozbun MA, Bondu V, Patterson NA, Sterk RT, Waxman AG, Bennett EC, McKee R, Sharma A, Yarwood J, Rogers M, Eichenbaum G.
Ozbun MA, et al. Among authors: sterk rt.
EBioMedicine. 2021 Jan;63:103165. doi: 10.1016/j.ebiom.2020.103165. Epub 2021 Jan 7.
EBioMedicine. 2021.
PMID: 33422988
Free PMC article.
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Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3-kinase/Akt/mTOR pathway and inhibition of autophagy.
Surviladze Z, Sterk RT, DeHaro SA, Ozbun MA.
Surviladze Z, et al. Among authors: sterk rt.
J Virol. 2013 Mar;87(5):2508-17. doi: 10.1128/JVI.02319-12. Epub 2012 Dec 19.
J Virol. 2013.
PMID: 23255786
Free PMC article.
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