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Novel S1P1 receptor agonists - Part 5: From amino-to alkoxy-pyridines.
Bolli MH, Lescop C, Birker M, de Kanter R, Hess P, Kohl C, Nayler O, Rey M, Sieber P, Velker J, Weller T, Steiner B. Bolli MH, et al. Among authors: steiner b. Eur J Med Chem. 2016 Jun 10;115:326-41. doi: 10.1016/j.ejmech.2016.03.020. Epub 2016 Mar 12. Eur J Med Chem. 2016. PMID: 27027817
Cenerimod, a novel selective S1P1 receptor modulator with unique signaling properties.
Piali L, Birker-Robaczewska M, Lescop C, Froidevaux S, Schmitz N, Morrison K, Kohl C, Rey M, Studer R, Vezzali E, Hess P, Clozel M, Steiner B, Bolli MH, Nayler O. Piali L, et al. Among authors: steiner b. Pharmacol Res Perspect. 2017 Dec;5(6):e00370. doi: 10.1002/prp2.370. Pharmacol Res Perspect. 2017. PMID: 29226621 Free PMC article.
2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.
Bolli MH, Abele S, Binkert C, Bravo R, Buchmann S, Bur D, Gatfield J, Hess P, Kohl C, Mangold C, Mathys B, Menyhart K, Müller C, Nayler O, Scherz M, Schmidt G, Sippel V, Steiner B, Strasser D, Treiber A, Weller T. Bolli MH, et al. Among authors: steiner b. J Med Chem. 2010 May 27;53(10):4198-211. doi: 10.1021/jm100181s. J Med Chem. 2010. PMID: 20446681
Novel S1P1 receptor agonists--part 1: From pyrazoles to thiophenes.
Bolli MH, Müller C, Mathys B, Abele S, Birker M, Bravo R, Bur D, Hess P, Kohl C, Lehmann D, Nayler O, Rey M, Meyer S, Scherz M, Schmidt G, Steiner B, Treiber A, Velker J, Weller T. Bolli MH, et al. Among authors: steiner b. J Med Chem. 2013 Dec 12;56(23):9737-55. doi: 10.1021/jm4014373. Epub 2013 Nov 22. J Med Chem. 2013. PMID: 24266709
Novel S1P(1) receptor agonists--part 3: from thiophenes to pyridines.
Bolli MH, Abele S, Birker M, Bravo R, Bur D, de Kanter R, Kohl C, Grimont J, Hess P, Lescop C, Mathys B, Müller C, Nayler O, Rey M, Scherz M, Schmidt G, Seifert J, Steiner B, Velker J, Weller T. Bolli MH, et al. Among authors: steiner b. J Med Chem. 2014 Jan 9;57(1):110-30. doi: 10.1021/jm4014696. Epub 2013 Dec 24. J Med Chem. 2014. PMID: 24367923
4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel.
Caroff E, Hubler F, Meyer E, Renneberg D, Gnerre C, Treiber A, Rey M, Hess P, Steiner B, Hilpert K, Riederer MA. Caroff E, et al. Among authors: steiner b. J Med Chem. 2015 Dec 10;58(23):9133-53. doi: 10.1021/acs.jmedchem.5b00933. Epub 2015 Nov 18. J Med Chem. 2015. PMID: 26550844
Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.
Bezençon O, Bur D, Weller T, Richard-Bildstein S, Remen L, Sifferlen T, Corminboeuf O, Grisostomi C, Boss C, Prade L, Delahaye S, Treiber A, Strickner P, Binkert C, Hess P, Steiner B, Fischli W. Bezençon O, et al. Among authors: steiner b. J Med Chem. 2009 Jun 25;52(12):3689-702. doi: 10.1021/jm900022f. J Med Chem. 2009. PMID: 19358611
682 results