Stein D - Search Results

1

Genome-wide prediction of pathogenic gain- and loss-of-function variants from ensemble learning of a diverse feature set.

Stein D, Kars ME, Wu Y, Bayrak ÇS, Stenson PD, Cooper DN, Schlessinger A, Itan Y. Stein D, et al. Genome Med. 2023 Nov 30;15(1):103. doi: 10.1186/s13073-023-01261-9. Genome Med. 2023. PMID: 38037155 Free PMC article.

2

Identification of discriminative gene-level and protein-level features associated with pathogenic gain-of-function and loss-of-function variants.

Sevim Bayrak C, Stein D, Jain A, Chaudhary K, Nadkarni GN, Van Vleck TT, Puel A, Boisson-Dupuis S, Okada S, Stenson PD, Cooper DN, Schlessinger A, Itan Y. Sevim Bayrak C, et al. Among authors: stein d. Am J Hum Genet. 2021 Dec 2;108(12):2301-2318. doi: 10.1016/j.ajhg.2021.10.007. Epub 2021 Nov 10. Am J Hum Genet. 2021. PMID: 34762822 Free PMC article.

3

Structural signatures: a web server for exploring a database of and generating protein structural features from human cell lines and tissues.

Zatorski N, Stein D, Rahman R, Iyengar R, Schlessinger A. Zatorski N, et al. Among authors: stein d. Database (Oxford). 2022 Jul 26;2022:baac053. doi: 10.1093/database/baac053. Database (Oxford). 2022. PMID: 35881481 Free PMC article.

4

Structural Analysis of Genomic and Proteomic Signatures Reveal Dynamic Expression of Intrinsically Disordered Regions in Breast Cancer and Tissue.

Zatorski N, Sun Y, Elmas A, Dallago C, Karl T, Stein D, Rost B, Huang KL, Walsh M, Schlessinger A. Zatorski N, et al. Among authors: stein d. bioRxiv [Preprint]. 2023 Feb 24:2023.02.23.529755. doi: 10.1101/2023.02.23.529755. bioRxiv. 2023. PMID: 36865220 Free PMC article. Preprint.

5

Exploring the Druggable Conformational Space of Protein Kinases Using AI-Generated Structures.

Herrington NB, Stein D, Li YC, Pandey G, Schlessinger A. Herrington NB, et al. Among authors: stein d. bioRxiv [Preprint]. 2023 Sep 2:2023.08.31.555779. doi: 10.1101/2023.08.31.555779. bioRxiv. 2023. PMID: 37693436 Free PMC article. Preprint.

6

Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications.

Duffy Á, Petrazzini BO, Stein D, Park JK, Forrest IS, Gibson K, Vy HM, Chen R, Márquez-Luna C, Mort M, Verbanck M, Schlessinger A, Itan Y, Cooper DN, Rocheleau G, Jordan DM, Do R. Duffy Á, et al. Among authors: stein d. Nat Genet. 2024 Jan;56(1):51-59. doi: 10.1038/s41588-023-01609-2. Epub 2024 Jan 3. Nat Genet. 2024. PMID: 38172303

7

Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis.

Horesh ME, Martin-Fernandez M, Gruber C, Buta S, Le Voyer T, Puzenat E, Lesmana H, Wu Y, Richardson A, Stein D, Hodeib S, Youssef M, Kurowski JA, Feuille E, Pedroza LA, Fuleihan RL, Haseley A, Hovnanian A, Quartier P, Rosain J, Davis G, Mullan D, Stewart O, Patel R, Lee AE, Rubinstein R, Ewald L, Maheshwari N, Rahming V, Chinn IK, Lupski JR, Orange JS, Sancho-Shimizu V, Casanova JL, Abul-Husn NS, Itan Y, Milner JD, Bustamante J, Bogunovic D. Horesh ME, et al. Among authors: stein d. J Exp Med. 2024 Jun 3;221(6):e20232387. doi: 10.1084/jem.20232387. Epub 2024 Apr 2. J Exp Med. 2024. PMID: 38563820

8

Early pharmacological interventions for prevention of post-traumatic stress disorder (PTSD) in individuals experiencing acute traumatic stress symptoms.

Bertolini F, Robertson L, Bisson JI, Meader N, Churchill R, Ostuzzi G, Stein DJ, Williams T, Barbui C. Bertolini F, et al. Among authors: stein dj. Cochrane Database Syst Rev. 2024 May 20;5:CD013613. doi: 10.1002/14651858.CD013613.pub2. Cochrane Database Syst Rev. 2024. PMID: 38767196 Review.

9

Burden of disease scenarios for 204 countries and territories, 2022-2050: a forecasting analysis for the Global Burden of Disease Study 2021.

GBD 2021 Forecasting Collaborators. GBD 2021 Forecasting Collaborators. Lancet. 2024 May 18;403(10440):2204-2256. doi: 10.1016/S0140-6736(24)00685-8. Lancet. 2024. PMID: 38762325 Free article.

10

Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.

GBD 2021 Risk Factors Collaborators. GBD 2021 Risk Factors Collaborators. Lancet. 2024 May 18;403(10440):2162-2203. doi: 10.1016/S0140-6736(24)00933-4. Lancet. 2024. PMID: 38762324 Free article.

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