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Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication.
Stegmann KM, Dickmanns A, Heinen N, Blaurock C, Karrasch T, Breithaupt A, Klopfleisch R, Uhlig N, Eberlein V, Issmail L, Herrmann ST, Schreieck A, Peelen E, Kohlhof H, Sadeghi B, Riek A, Speakman JR, Groß U, Görlich D, Vitt D, Müller T, Grunwald T, Pfaender S, Balkema-Buschmann A, Dobbelstein M. Stegmann KM, et al. iScience. 2022 May 20;25(5):104293. doi: 10.1016/j.isci.2022.104293. Epub 2022 Apr 25. iScience. 2022. PMID: 35492218 Free PMC article.
The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models.
Stegmann KM, Dickmanns A, Gerber S, Nikolova V, Klemke L, Manzini V, Schlösser D, Bierwirth C, Freund J, Sitte M, Lugert R, Salinas G, Meister TL, Pfaender S, Görlich D, Wollnik B, Groß U, Dobbelstein M. Stegmann KM, et al. Virus Res. 2021 Sep;302:198469. doi: 10.1016/j.virusres.2021.198469. Epub 2021 Jun 6. Virus Res. 2021. PMID: 34090962 Free PMC article.
Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies.
Güttler T, Aksu M, Dickmanns A, Stegmann KM, Gregor K, Rees R, Taxer W, Rymarenko O, Schünemann J, Dienemann C, Gunkel P, Mussil B, Krull J, Teichmann U, Groß U, Cordes VC, Dobbelstein M, Görlich D. Güttler T, et al. Among authors: stegmann km. EMBO J. 2021 Oct 1;40(19):e107985. doi: 10.15252/embj.2021107985. Epub 2021 Aug 9. EMBO J. 2021. PMID: 34302370 Free PMC article.
N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody.
Zibat A, Zhang X, Dickmanns A, Stegmann KM, Dobbelstein AW, Alachram H, Soliwoda R, Salinas G, Groß U, Görlich D, Kschischo M, Wollnik B, Dobbelstein M. Zibat A, et al. Among authors: stegmann km. iScience. 2023 Aug 30;26(10):107786. doi: 10.1016/j.isci.2023.107786. eCollection 2023 Oct 20. iScience. 2023. PMID: 37731621 Free PMC article.
Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters.
Aksu M, Kumar P, Güttler T, Taxer W, Gregor K, Mußil B, Rymarenko O, Stegmann KM, Dickmanns A, Gerber S, Reineking W, Schulz C, Henneck T, Mohamed A, Pohlmann G, Ramazanoglu M, Mese K, Groß U, Ben-Yedidia T, Ovadia O, Fischer DW, Kamensky M, Reichman A, Baumgärtner W, von Köckritz-Blickwede M, Dobbelstein M, Görlich D. Aksu M, et al. Among authors: stegmann km. Antiviral Res. 2024 Jan;221:105778. doi: 10.1016/j.antiviral.2023.105778. Epub 2023 Dec 7. Antiviral Res. 2024. PMID: 38065245 Free article.
Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design.
Funk LM, Poschmann G, Rabe von Pappenheim F, Chari A, Stegmann KM, Dickmanns A, Wensien M, Eulig N, Paknia E, Heyne G, Penka E, Pearson AR, Berndt C, Fritz T, Bazzi S, Uranga J, Mata RA, Dobbelstein M, Hilgenfeld R, Curth U, Tittmann K. Funk LM, et al. Among authors: stegmann km. Nat Commun. 2024 Jan 9;15(1):411. doi: 10.1038/s41467-023-44621-0. Nat Commun. 2024. PMID: 38195625 Free PMC article.
Evaluation of N4-hydroxycytidine incorporation into nucleic acids of SARS-CoV-2-infected host cells by direct measurement with liquid chromatography-mass spectrometry.
Urbanowicz K, Opielka M, Stegmann KM, Dickmanns A, Dobbelstein M, Peters GJ, Smoleński RT. Urbanowicz K, et al. Among authors: stegmann km. Nucleosides Nucleotides Nucleic Acids. 2024 May 13:1-9. doi: 10.1080/15257770.2024.2346550. Online ahead of print. Nucleosides Nucleotides Nucleic Acids. 2024. PMID: 38741480