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eTRANSAFE: data science to empower translational safety assessment.
Sanz F, Pognan F, Steger-Hartmann T, Díaz C, Asakura S, Amberg A, Bécourt-Lhote N, Blomberg N, Bosc N, Briggs K, Bringezu F, Brulle-Wohlhueter C, Brunak S, Bueters R, Callegaro G, Capella-Gutierrez S, Centeno E, Corvi J, Cronin MTD, Drew P, Duchateau-Nguyen G, Ecker GF, Escher S, Felix E, Ferreiro M, Frericks M, Furlong LI, Geiger R, George C, Grandits M, Ivanov-Draganov D, Kilgour-Christie J, Kiziloren T, Kors JA, Koyama N, Kreuchwig A, Leach AR, Mayer MA, Monecke P, Muster W, Nakazawa CM, Nicholson G, Parry R, Pastor M, Piñero J, Oberhauser N, Ramírez-Anguita JM, Rodrigo A, Smajic A, Schaefer M, Schieferdecker S, Soininen I, Terricabras E, Trairatphisan P, Turner SC, Valencia A, van de Water B, van der Lei JL, van Mulligen EM, Vock E, Wilkinson D. Sanz F, et al. Among authors: steger hartmann t. Nat Rev Drug Discov. 2023 Aug;22(8):605-606. doi: 10.1038/d41573-023-00099-5. Nat Rev Drug Discov. 2023. PMID: 37316648 No abstract available.
Toward implementing virtual control groups in nonclinical safety studies.
Golden E, Allen D, Amberg A, Anger LT, Baker E, Baran SW, Bringezu F, Clark M, Duchateau-Nguyen G, Escher SE, Giri V, Grevot A, Hartung T, Li D, Lotfi L, Muster W, Snyder K, Wange R, Steger-Hartmann T. Golden E, et al. Among authors: steger hartmann t. ALTEX. 2024;41(2):282-301. doi: 10.14573/altex.2310041. Epub 2023 Dec 1. ALTEX. 2024. PMID: 38043132 Free article.
Points to consider regarding the use and implementation of virtual controls in nonclinical general toxicology studies.
Palazzi X, Anger LT, Boulineau T, Grevot A, Guffroy M, Henson K, Hoepp N, Jacobsen M, Kale VP, Kreeger J, Lane JH, Li D, Muster W, Paisley B, Ramaiah L, Robertson N, Shultz V, Steger Hartmann T, Westhouse R. Palazzi X, et al. Among authors: steger hartmann t. Regul Toxicol Pharmacol. 2024 Apr 27;150:105632. doi: 10.1016/j.yrtph.2024.105632. Online ahead of print. Regul Toxicol Pharmacol. 2024. PMID: 38679316
Editorial: Advances in and applications of predictive toxicology: 2022.
Najjar A, Kramer N, Gardner I, Hartung T, Steger-Hartmann T. Najjar A, et al. Among authors: steger hartmann t. Front Pharmacol. 2023 Aug 2;14:1257423. doi: 10.3389/fphar.2023.1257423. eCollection 2023. Front Pharmacol. 2023. PMID: 37601064 Free PMC article. No abstract available.
Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis.
Hilpert J, Groettrup-Wolfers E, Kosturski H, Bennett L, Barnes CLK, Gude K, Gashaw I, Reif S, Steger-Hartmann T, Scheerans C, Solms A, Rottmann A, Mao G, Chapron C. Hilpert J, et al. Among authors: steger hartmann t. Drugs R D. 2023 Sep;23(3):221-237. doi: 10.1007/s40268-023-00427-5. Epub 2023 Jul 9. Drugs R D. 2023. PMID: 37422772 Free PMC article. Clinical Trial.
Perspectives of data science in preclinical safety assessment.
Steger-Hartmann T, Kreuchwig A, Wang K, Birzele F, Draganov D, Gaudio S, Rothfuss A. Steger-Hartmann T, et al. Drug Discov Today. 2023 Aug;28(8):103642. doi: 10.1016/j.drudis.2023.103642. Epub 2023 May 26. Drug Discov Today. 2023. PMID: 37244565 Review.
The evolving role of investigative toxicology in the pharmaceutical industry.
Pognan F, Beilmann M, Boonen HCM, Czich A, Dear G, Hewitt P, Mow T, Oinonen T, Roth A, Steger-Hartmann T, Valentin JP, Van Goethem F, Weaver RJ, Newham P. Pognan F, et al. Among authors: steger hartmann t. Nat Rev Drug Discov. 2023 Apr;22(4):317-335. doi: 10.1038/s41573-022-00633-x. Epub 2023 Feb 13. Nat Rev Drug Discov. 2023. PMID: 36781957 Free PMC article. Review.
61 results