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High-throughput screening identified inherited genetic variations in the EGFR pathway contributing to skin toxicity of EGFR inhibitors.
Hasheminasab SM, Tzvetkov MV, Schumann C, Rüdiger S, Boeck S, Heinemann V, Kächele V, Steffens M, Scholl C, Hichert V, Seufferlein T, Brockmöller J, Stingl JC. Hasheminasab SM, et al. Among authors: steffens m. Pharmacogenomics. 2015;16(14):1605-19. doi: 10.2217/pgs.15.97. Epub 2015 Sep 30. Pharmacogenomics. 2015. PMID: 26419366
Dosing to rash?--The role of erlotinib metabolic ratio from patient serum in the search of predictive biomarkers for EGFR inhibitor-mediated skin rash.
Steffens M, Paul T, Hichert V, Scholl C, von Mallek D, Stelzer C, Sörgel F, Reiser B, Schumann C, Rüdiger S, Boeck S, Heinemann V, Kächele V, Seufferlein T, Stingl J. Steffens M, et al. Eur J Cancer. 2016 Mar;55:131-9. doi: 10.1016/j.ejca.2015.11.022. Epub 2016 Jan 25. Eur J Cancer. 2016. PMID: 26820683
Predictive blood plasma biomarkers for EGFR inhibitor-induced skin rash.
Hichert V, Scholl C, Steffens M, Paul T, Schumann C, Rüdiger S, Boeck S, Heinemann V, Kächele V, Seufferlein T, Stingl J. Hichert V, et al. Among authors: steffens m. Oncotarget. 2017 May 23;8(21):35193-35204. doi: 10.18632/oncotarget.17060. Oncotarget. 2017. PMID: 28456787 Free PMC article.
434 results