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A Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of a First-in-Human Engineered Cationic Peptide, PLG0206, Intravenously Administered in Healthy Subjects.
Huang D, Dobbins D, Ghahramani P, Friedland I, Steckbeck J. Huang D, et al. Among authors: steckbeck j. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0144121. doi: 10.1128/AAC.01441-21. Epub 2021 Nov 22. Antimicrob Agents Chemother. 2022. PMID: 34807760 Free PMC article. Clinical Trial.
Engineered peptide PLG0206 overcomes limitations of a challenging antimicrobial drug class.
Huang DB, Brothers KM, Mandell JB, Taguchi M, Alexander PG, Parker DM, Shinabarger D, Pillar C, Morrissey I, Hawser S, Ghahramani P, Dobbins D, Pachuda N, Montelaro R, Steckbeck JD, Urish KL. Huang DB, et al. Among authors: steckbeck jd. PLoS One. 2022 Sep 16;17(9):e0274815. doi: 10.1371/journal.pone.0274815. eCollection 2022. PLoS One. 2022. PMID: 36112657 Free PMC article.
Prospective Activity of PLG0206, an Engineered Antimicrobial Peptide, on Chronic Periprosthetic Joint Infection Total Knee Arthroplasty Components Ex Vivo: The Knee Explant Analysis (KnEA) Study.
Huang D, Parker DM, Mandell JB, Brothers KM, Gish CG, Koch JA, Pachuda N, Dobbins D, Steckbeck J, Urish KL. Huang D, et al. Among authors: steckbeck j. Microbiol Spectr. 2021 Dec 22;9(3):e0187921. doi: 10.1128/Spectrum.01879-21. Epub 2021 Nov 24. Microbiol Spectr. 2021. PMID: 34817227 Free PMC article. Clinical Trial.
Antimicrobial peptides: new drugs for bad bugs?
Steckbeck JD, Deslouches B, Montelaro RC. Steckbeck JD, et al. Expert Opin Biol Ther. 2014 Jan;14(1):11-4. doi: 10.1517/14712598.2013.844227. Epub 2013 Nov 11. Expert Opin Biol Ther. 2014. PMID: 24206062 Free PMC article. Review.
29 results