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SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling.
Biering SB, Gomes de Sousa FT, Tjang LV, Pahmeier F, Zhu C, Ruan R, Blanc SF, Patel TS, Worthington CM, Glasner DR, Castillo-Rojas B, Servellita V, Lo NTN, Wong MP, Warnes CM, Sandoval DR, Clausen TM, Santos YA, Fox DM, Ortega V, Näär AM, Baric RS, Stanley SA, Aguilar HC, Esko JD, Chiu CY, Pak JE, Beatty PR, Harris E. Biering SB, et al. Among authors: stanley sa. Nat Commun. 2022 Dec 9;13(1):7630. doi: 10.1038/s41467-022-34910-5. Nat Commun. 2022. PMID: 36494335 Free PMC article.
Rapid, point-of-care molecular diagnostics with Cas13.
Agrawal S, Fanton A, Chandrasekaran SS, Charrez B, Escajeda AM, Son S, Mcintosh R, Bhuiya A, de León Derby MD, Switz NA, Armstrong M, Harris AR, Prywes N, Lukarska M, Biering SB, Smock DCJ, Mok A, Knott GJ, Dang Q, Van Dis E, Dugan E, Kim S, Liu TY; IGI Testing Consortium; Harris E, Stanley SA, Lareau LF, Tan MX, Fletcher DA, Doudna JA, Savage DF, Hsu PD. Agrawal S, et al. Among authors: stanley sa. medRxiv [Preprint]. 2021 Apr 5:2020.12.14.20247874. doi: 10.1101/2020.12.14.20247874. medRxiv. 2021. PMID: 33354689 Free PMC article. Preprint.
Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2.
Biering SB, Van Dis E, Wehri E, Yamashiro LH, Nguyenla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze-Gamen U, Bajaj R, Fox DM, Ott M, Murthy N, Nomura DK, Schaletzky J, Stanley SA. Biering SB, et al. Among authors: stanley sa. ACS Infect Dis. 2021 Aug 13;7(8):2337-2351. doi: 10.1021/acsinfecdis.1c00017. Epub 2021 Jun 15. ACS Infect Dis. 2021. PMID: 34129317
SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA.
Jack A, Ferro LS, Trnka MJ, Wehri E, Nadgir A, Nguyenla X, Fox D, Costa K, Stanley S, Schaletzky J, Yildiz A. Jack A, et al. PLoS Biol. 2021 Oct 11;19(10):e3001425. doi: 10.1371/journal.pbio.3001425. eCollection 2021 Oct. PLoS Biol. 2021. PMID: 34634033 Free PMC article.
The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters.
Carroll T, Fox D, van Doremalen N, Ball E, Morris MK, Sotomayor-Gonzalez A, Servellita V, Rustagi A, Yinda CK, Fritts L, Port JR, Ma ZM, Holbrook MG, Schulz J, Blish CA, Hanson C, Chiu CY, Munster V, Stanley S, Miller CJ. Carroll T, et al. PLoS Pathog. 2022 Feb 10;18(2):e1009914. doi: 10.1371/journal.ppat.1009914. eCollection 2022 Feb. PLoS Pathog. 2022. PMID: 35143587 Free PMC article.
Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro.
Zeng L, Liu Y, Nguyenla XH, Abbott TR, Han M, Zhu Y, Chemparathy A, Lin X, Chen X, Wang H, Rane DA, Spatz JM, Jain S, Rustagi A, Pinsky B, Zepeda AE, Kadina AP, Walker JA 3rd, Holden K, Temperton N, Cochran JR, Barron AE, Connolly MD, Blish CA, Lewis DB, Stanley SA, La Russa MF, Qi LS. Zeng L, et al. Among authors: stanley sa. Nat Commun. 2022 May 19;13(1):2766. doi: 10.1038/s41467-022-30546-7. Nat Commun. 2022. PMID: 35589813 Free PMC article.
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.
Biering SB, Sarnik SA, Wang E, Zengel JR, Leist SR, Schäfer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Nguyenla X, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS, Button B, Pinsky BA, Blish CA, Baric RS, O'Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E, Konermann S, Hsu PD. Biering SB, et al. Among authors: stanley sa. Nat Genet. 2022 Aug;54(8):1078-1089. doi: 10.1038/s41588-022-01131-x. Epub 2022 Jul 25. Nat Genet. 2022. PMID: 35879412 Free PMC article.
An intranasal ASO therapeutic targeting SARS-CoV-2.
Zhu C, Lee JY, Woo JZ, Xu L, Nguyenla X, Yamashiro LH, Ji F, Biering SB, Van Dis E, Gonzalez F, Fox D, Wehri E, Rustagi A, Pinsky BA, Schaletzky J, Blish CA, Chiu C, Harris E, Sadreyev RI, Stanley S, Kauppinen S, Rouskin S, Näär AM. Zhu C, et al. Nat Commun. 2022 Aug 3;13(1):4503. doi: 10.1038/s41467-022-32216-0. Nat Commun. 2022. PMID: 35922434 Free PMC article.
122 results