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Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts.
Rodríguez-Hernández D, Vijayan K, Zigweid R, Fenwick MK, Sankaran B, Roobsoong W, Sattabongkot J, Glennon EKK, Myler PJ, Sunnerhagen P, Staker BL, Kaushansky A, Grøtli M. Rodríguez-Hernández D, et al. Among authors: staker bl. Nat Commun. 2023 Sep 5;14(1):5408. doi: 10.1038/s41467-023-41119-7. Nat Commun. 2023. PMID: 37669940 Free PMC article.
Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors.
Ameriks MK, Bembenek SD, Burdett MT, Choong IC, Edwards JP, Gebauer D, Gu Y, Karlsson L, Purkey HE, Staker BL, Sun S, Thurmond RL, Zhu J. Ameriks MK, et al. Among authors: staker bl. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4060-4. doi: 10.1016/j.bmcl.2010.05.086. Epub 2010 May 25. Bioorg Med Chem Lett. 2010. PMID: 20541404
The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS).
Gerdts CJ, Elliott M, Lovell S, Mixon MB, Napuli AJ, Staker BL, Nollert P, Stewart L. Gerdts CJ, et al. Among authors: staker bl. Acta Crystallogr D Biol Crystallogr. 2008 Nov;64(Pt 11):1116-22. doi: 10.1107/S0907444908028060. Epub 2008 Oct 18. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 19020349 Free PMC article.
Active site in RrmJ, a heat shock-induced methyltransferase.
Hager J, Staker BL, Bugl H, Jakob U. Hager J, et al. Among authors: staker bl. J Biol Chem. 2002 Nov 1;277(44):41978-86. doi: 10.1074/jbc.M205423200. Epub 2002 Aug 13. J Biol Chem. 2002. PMID: 12181314 Free article.
DcpS as a therapeutic target for spinal muscular atrophy.
Singh J, Salcius M, Liu SW, Staker BL, Mishra R, Thurmond J, Michaud G, Mattoon DR, Printen J, Christensen J, Bjornsson JM, Pollok BA, Kiledjian M, Stewart L, Jarecki J, Gurney ME. Singh J, et al. Among authors: staker bl. ACS Chem Biol. 2008 Nov 21;3(11):711-22. doi: 10.1021/cb800120t. ACS Chem Biol. 2008. PMID: 18839960 Free PMC article.
Gene Composer in a structural genomics environment.
Lorimer D, Raymond A, Mixon M, Burgin A, Staker B, Stewart L. Lorimer D, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):985-91. doi: 10.1107/S1744309111027424. Epub 2011 Aug 13. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 21904038 Free PMC article.
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