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Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus.
Mohammed S, Vineetha NS, James S, Aparna JS, Lankadasari MB, Allegood JC, Li QZ, Spiegel S, Harikumar KB. Mohammed S, et al. Among authors: spiegel s. FASEB J. 2019 Jun;33(6):7061-7071. doi: 10.1096/fj.201802535R. Epub 2019 Mar 6. FASEB J. 2019. PMID: 30840833 Free PMC article.
Yet, because its deletion had no effect on the clinical lupus parameters in this preclinical model, inhibitors of SphK2 might not be useful for treatment of this devastating disease.-Mohammed, S., Vineetha, N. S., James, S., Aparna, J. S., Lankadasari, …
Yet, because its deletion had no effect on the clinical lupus parameters in this preclinical model, inhibitors of SphK2 might not be useful …
Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma.
Olivera A, Edsall L, Poulton S, Kazlauskas A, Spiegel S. Olivera A, et al. Among authors: spiegel s. FASEB J. 1999 Sep;13(12):1593-600. doi: 10.1096/fasebj.13.12.1593. FASEB J. 1999. PMID: 10463951
Moreover, calcium mobilization downstream of PLCgamma, but not protein kinase C activation, appears to be required for stimulation of sphingosine kinase by PDGF.-Olivera, A., Edsall, J., Poulton, S., Kazlauskas, A., Spiegel, S. Platelet-derived growth factor- …
Moreover, calcium mobilization downstream of PLCgamma, but not protein kinase C activation, appears to be required for stimulation of sphing …
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.
Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S. Liu H, et al. Among authors: spiegel s. J Biol Chem. 2000 Jun 30;275(26):19513-20. doi: 10.1074/jbc.M002759200. J Biol Chem. 2000. PMID: 10751414 Free article.
Based on sequence homology to murine and human sphingosine kinase-1 (SPHK1), which we recently cloned (Kohama, T., Oliver, A., Edsall, L. , Nagiec, M. M., Dickson, R., and Spiegel, S. (1998) J. Biol. Chem. 273, 23722-23728), we have now cloned a second type of mouse …
Based on sequence homology to murine and human sphingosine kinase-1 (SPHK1), which we recently cloned (Kohama, T., Oliver, A., Edsall, L. , …
Sphingosine kinases: a novel family of lipid kinases.
Liu H, Chakravarty D, Maceyka M, Milstien S, Spiegel S. Liu H, et al. Among authors: spiegel s. Prog Nucleic Acid Res Mol Biol. 2002;71:493-511. doi: 10.1016/s0079-6603(02)71049-0. Prog Nucleic Acid Res Mol Biol. 2002. PMID: 12102559 Review.
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis.
Maceyka M, Payne SG, Milstien S, Spiegel S. Maceyka M, et al. Among authors: spiegel s. Biochim Biophys Acta. 2002 Dec 30;1585(2-3):193-201. doi: 10.1016/s1388-1981(02)00341-4. Biochim Biophys Acta. 2002. PMID: 12531554 Review.
491 results