Spassov DS - Search Results

1

A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF^V600E colorectal tumors.

Ruiz-Saenz A, Atreya CE, Wang C, Pan B, Dreyer CA, Brunen D, Prahallad A, Muñoz DP, Ramms DJ, Burghi V, Spassov DS, Fewings E, Hwang YC, Cowdrey C, Moelders C, Schwarzer C, Wolf DM, Hann B, VandenBerg SR, Shokat K, Moasser MM, Bernards R, Gutkind JS, van 't Veer LJ, Coppé JP. Ruiz-Saenz A, et al. Among authors: spassov ds. Nat Cancer. 2023 Feb;4(2):240-256. doi: 10.1038/s43018-022-00508-5. Epub 2023 Feb 9. Nat Cancer. 2023. PMID: 36759733 Free PMC article.

2

Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers.

Wong CH, Baehner FL, Spassov DS, Ahuja D, Wang D, Hann B, Blair J, Shokat K, Welm AL, Moasser MM. Wong CH, et al. Among authors: spassov ds. Clin Cancer Res. 2009 Apr 1;15(7):2311-22. doi: 10.1158/1078-0432.CCR-08-2533. Epub 2009 Mar 24. Clin Cancer Res. 2009. PMID: 19318475 Free PMC article.

3

The transmembrane src substrate Trask is an epithelial protein that signals during anchorage deprivation.

Spassov DS, Baehner FL, Wong CH, McDonough S, Moasser MM. Spassov DS, et al. Am J Pathol. 2009 May;174(5):1756-65. doi: 10.2353/ajpath.2009.080890. Epub 2009 Apr 6. Am J Pathol. 2009. PMID: 19349359 Free PMC article.

4

Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling.

Spassov DS, Wong CH, Sergina N, Ahuja D, Fried M, Sheppard D, Moasser MM. Spassov DS, et al. Mol Cell Biol. 2011 Feb;31(4):766-82. doi: 10.1128/MCB.00841-10. Epub 2010 Dec 28. Mol Cell Biol. 2011. PMID: 21189288 Free PMC article.

5

Trask phosphorylation defines the reverse mode of a phosphotyrosine signaling switch that underlies cell anchorage state.

Spassov DS, Wong CH, Moasser MM. Spassov DS, et al. Cell Cycle. 2011 Apr 15;10(8):1225-32. doi: 10.4161/cc.10.8.15343. Epub 2011 Apr 15. Cell Cycle. 2011. PMID: 21490433 Free PMC article.

6

The structural features of Trask that mediate its anti-adhesive functions.

Spassov DS, Ahuja D, Wong CH, Moasser MM. Spassov DS, et al. PLoS One. 2011 Apr 29;6(4):e19154. doi: 10.1371/journal.pone.0019154. PLoS One. 2011. PMID: 21559459 Free PMC article.

7

A tumor-suppressing function in the epithelial adhesion protein Trask.

Spassov DS, Wong CH, Harris G, McDonough S, Phojanakong P, Wang D, Hann B, Bazarov AV, Yaswen P, Khanafshar E, Moasser MM. Spassov DS, et al. Oncogene. 2012 Jan 26;31(4):419-31. doi: 10.1038/onc.2011.246. Epub 2011 Jun 27. Oncogene. 2012. PMID: 21706059 Free PMC article.

8

Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells.

Spassov DS, Wong CH, Wong SY, Reiter JF, Moasser MM. Spassov DS, et al. Cancer Res. 2013 Feb 1;73(3):1168-79. doi: 10.1158/0008-5472.CAN-12-2496. Epub 2012 Dec 12. Cancer Res. 2013. PMID: 23243018 Free PMC article.

9

CD318 is a ligand for CD6.

Enyindah-Asonye G, Li Y, Ruth JH, Spassov DS, Hebron KE, Zijlstra A, Moasser MM, Wang B, Singer NG, Cui H, Ohara RA, Rasmussen SM, Fox DA, Lin F. Enyindah-Asonye G, et al. Among authors: spassov ds. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6912-E6921. doi: 10.1073/pnas.1704008114. Epub 2017 Jul 31. Proc Natl Acad Sci U S A. 2017. PMID: 28760953 Free PMC article.

10

A Dimerization Function in the Intrinsically Disordered N-Terminal Region of Src.

Spassov DS, Ruiz-Saenz A, Piple A, Moasser MM. Spassov DS, et al. Cell Rep. 2018 Oct 9;25(2):449-463.e4. doi: 10.1016/j.celrep.2018.09.035. Cell Rep. 2018. PMID: 30304684 Free PMC article.

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