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PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
Berlin M, Cantley J, Bookbinder M, Bortolon E, Broccatelli F, Cadelina G, Chan EW, Chen H, Chen X, Cheng Y, Cheung TK, Davenport K, DiNicola D, Gordon D, Hamman BD, Harbin A, Haskell R, He M, Hole AJ, Januario T, Kerry PS, Koenig SG, Li L, Merchant M, Pérez-Dorado I, Pizzano J, Quinn C, Rose CM, Rousseau E, Soto L, Staben LR, Sun H, Tian Q, Wang J, Wang W, Ye CS, Ye X, Zhang P, Zhou Y, Yauch R, Dragovich PS. Berlin M, et al. Among authors: soto l. J Med Chem. 2024 Jan 25;67(2):1262-1313. doi: 10.1021/acs.jmedchem.3c01781. Epub 2024 Jan 5. J Med Chem. 2024. PMID: 38180485
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.
Cantley J, Ye X, Rousseau E, Januario T, Hamman BD, Rose CM, Cheung TK, Hinkle T, Soto L, Quinn C, Harbin A, Bortolon E, Chen X, Haskell R, Lin E, Yu SF, Del Rosario G, Chan E, Dunlap D, Koeppen H, Martin S, Merchant M, Grimmer M, Broccatelli F, Wang J, Pizzano J, Dragovich PS, Berlin M, Yauch RL. Cantley J, et al. Among authors: soto l. Nat Commun. 2022 Nov 10;13(1):6814. doi: 10.1038/s41467-022-34562-5. Nat Commun. 2022. PMID: 36357397 Free PMC article.
Multi-Institutional Audit of FLASH and Conventional Dosimetry With a 3D Printed Anatomically Realistic Mouse Phantom.
Ashraf MR, Melemenidis S, Liu K, Grilj V, Jansen J, Velasquez B, Connell L, Schulz JB, Bailat C, Libed A, Manjappa R, Dutt S, Soto L, Lau B, Garza A, Larsen W, Skinner L, Yu AS, Surucu M, Graves EE, Maxim PG, Kry SF, Vozenin MC, Schüler E, Loo BW Jr. Ashraf MR, et al. Among authors: soto l. Int J Radiat Oncol Biol Phys. 2024 Mar 15:S0360-3016(24)00433-4. doi: 10.1016/j.ijrobp.2024.03.017. Online ahead of print. Int J Radiat Oncol Biol Phys. 2024. PMID: 38493902
Exploring Deep Learning for Estimating the Isoeffective Dose of FLASH Irradiation From Mouse Intestinal Histological Images.
Fu J, Yang Z, Melemenidis S, Viswanathan V, Dutt S, Manjappa R, Lau B, Soto LA, Ashraf MR, Skinner L, Yu SJ, Surucu M, Casey KM, Rankin EB, Graves E, Lu W, Loo BW Jr, Gu X. Fu J, et al. Among authors: soto la. Int J Radiat Oncol Biol Phys. 2024 Jan 1:S0360-3016(23)08306-2. doi: 10.1016/j.ijrobp.2023.12.032. Online ahead of print. Int J Radiat Oncol Biol Phys. 2024. PMID: 38171387
316 results