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CFI-402257, a TTK inhibitor, effectively suppresses hepatocellular carcinoma.
Chan CY, Chiu DK, Yuen VW, Law CT, Wong BP, Thu KL, Cescon DW, Soria-Bretones I, Cheu JW, Lee D, Tse AP, Zhang MS, Tan KV, Ng IO, Khong PL, Yau TC, Bray MR, Mak TW, Wong CC. Chan CY, et al. Among authors: soria bretones i. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2119514119. doi: 10.1073/pnas.2119514119. Epub 2022 Aug 1. Proc Natl Acad Sci U S A. 2022. PMID: 35914158 Free PMC article.
Polo-like kinase 4 inhibitor CFI-400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity.
Chan CY, Yuen VW, Chiu DK, Goh CC, Thu KL, Cescon DW, Soria-Bretones I, Law CT, Cheu JW, Lee D, Tse AP, Tan KV, Zhang MS, Wong BP, Wong CM, Khong PL, Ng IO, Bray MR, Mak TW, Yau TC, Wong CC. Chan CY, et al. Among authors: soria bretones i. Hepatology. 2023 Mar 1;77(3):729-744. doi: 10.1002/hep.32461. Epub 2023 Feb 17. Hepatology. 2023. PMID: 35302667
The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor-resistant ER+ breast cancer with mitotic aberrations.
Soria-Bretones I, Thu KL, Silvester J, Cruickshank J, El Ghamrasni S, Ba-Alawi W, Fletcher GC, Kiarash R, Elliott MJ, Chalmers JJ, Elia AC, Cheng A, Rose AAN, Bray MR, Haibe-Kains B, Mak TW, Cescon DW. Soria-Bretones I, et al. Sci Adv. 2022 Sep 9;8(36):eabq4293. doi: 10.1126/sciadv.abq4293. Epub 2022 Sep 7. Sci Adv. 2022. PMID: 36070391 Free PMC article.
Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies.
Hilton J, Gelmon K, Bedard PL, Tu D, Xu H, Tinker AV, Goodwin R, Laurie SA, Jonker D, Hansen AR, Veitch ZW, Renouf DJ, Hagerman L, Lui H, Chen B, Kellar D, Li I, Lee SE, Kono T, Cheng BYC, Yap D, Lai D, Beatty S, Soong J, Pritchard KI, Soria-Bretones I, Chen E, Feilotter H, Rushton M, Seymour L, Aparicio S, Cescon DW. Hilton J, et al. Among authors: soria bretones i. Nat Commun. 2022 Jun 24;13(1):3607. doi: 10.1038/s41467-022-31199-2. Nat Commun. 2022. PMID: 35750695 Free PMC article.
DNA end resection requires constitutive sumoylation of CtIP by CBX4.
Soria-Bretones I, Cepeda-García C, Checa-Rodriguez C, Heyer V, Reina-San-Martin B, Soutoglou E, Huertas P. Soria-Bretones I, et al. Nat Commun. 2017 Jul 24;8(1):113. doi: 10.1038/s41467-017-00183-6. Nat Commun. 2017. PMID: 28740167 Free PMC article.
Prognostic value of CtIP/RBBP8 expression in breast cancer.
Soria-Bretones I, Sáez C, Ruíz-Borrego M, Japón MA, Huertas P. Soria-Bretones I, et al. Cancer Med. 2013 Dec;2(6):774-83. doi: 10.1002/cam4.141. Epub 2013 Oct 3. Cancer Med. 2013. PMID: 24403251 Free PMC article.
The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.
Baranes-Bachar K, Levy-Barda A, Oehler J, Reid DA, Soria-Bretones I, Voss TC, Chung D, Park Y, Liu C, Yoon JB, Li W, Dellaire G, Misteli T, Huertas P, Rothenberg E, Ramadan K, Ziv Y, Shiloh Y. Baranes-Bachar K, et al. Mol Cell. 2018 Mar 1;69(5):866-878.e7. doi: 10.1016/j.molcel.2018.02.002. Mol Cell. 2018. PMID: 29499138 Free PMC article.
15 results