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Manganese increases Aβ and Tau protein levels through proteasome 20S and heat shock proteins 90 and 70 alteration, leading to SN56 cholinergic cell death following single and repeated treatment.
Moyano P, García JM, García J, Anadon MJ, Naval MV, Frejo MT, Sola E, Pelayo A, Pino JD. Moyano P, et al. Among authors: sola e. Ecotoxicol Environ Saf. 2020 Oct 15;203:110975. doi: 10.1016/j.ecoenv.2020.110975. Epub 2020 Jul 14. Ecotoxicol Environ Saf. 2020. PMID: 32678756
Bisphenol A single and repeated treatment increases HDAC2, leading to cholinergic neurotransmission dysfunction and SN56 cholinergic apoptotic cell death through AChE variants overexpression and NGF/TrkA/P75NTR signaling disruption.
Moyano P, Flores A, García J, García JM, Anadon MJ, Frejo MT, Sola E, Pelayo A, Del Pino J. Moyano P, et al. Among authors: sola e. Food Chem Toxicol. 2021 Nov;157:112614. doi: 10.1016/j.fct.2021.112614. Epub 2021 Oct 14. Food Chem Toxicol. 2021. PMID: 34655688
Single and repeated bisphenol A treatment induces ROS, Aβ and hyperphosphorylated-tau accumulation, and insulin pathways disruption, through HDAC2 and PTP1B overexpression, leading to SN56 cholinergic apoptotic cell death.
Flores A, Moyano P, Sola E, García JM, García J, Anadon MJ, Frejo MT, Naval MV, Fernadez MC, Pino JD. Flores A, et al. Among authors: sola e. Food Chem Toxicol. 2022 Dec;170:113500. doi: 10.1016/j.fct.2022.113500. Epub 2022 Oct 29. Food Chem Toxicol. 2022. PMID: 36374790
304 results