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Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice.
Zhang J, Sharma D, Dinabandhu A, Sanchez J, Applewhite B, Jee K, Deshpande M, Flores-Bellver M, Hu MW, Guo C, Salman S, Hwang Y, Anders NM, Rudek MA, Qian J, Canto-Soler MV, Semenza GL, Montaner S, Sodhi A. Zhang J, et al. Among authors: sodhi a. J Clin Invest. 2023 Jul 3;133(13):e163290. doi: 10.1172/JCI163290. J Clin Invest. 2023. PMID: 37227777 Free PMC article.
VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy.
Rodrigues M, Xin X, Jee K, Babapoor-Farrokhran S, Kashiwabuchi F, Ma T, Bhutto I, Hassan SJ, Daoud Y, Baranano D, Solomon S, Lutty G, Semenza GL, Montaner S, Sodhi A. Rodrigues M, et al. Among authors: sodhi a. Diabetes. 2013 Nov;62(11):3863-73. doi: 10.2337/db13-0014. Epub 2013 Jul 24. Diabetes. 2013. PMID: 23884892 Free PMC article.
Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4.
Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, Montaner S, Sodhi A. Xin X, et al. Among authors: sodhi a. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3425-34. doi: 10.1073/pnas.1217091110. Epub 2013 Aug 19. Proc Natl Acad Sci U S A. 2013. PMID: 23959876 Free PMC article.
Pro-Permeability Factors After Dexamethasone Implant in Retinal Vein Occlusion; the Ozurdex for Retinal Vein Occlusion (ORVO) Study.
Campochiaro PA, Hafiz G, Mir TA, Scott AW, Sophie R, Shah SM, Ying HS, Lu L, Chen C, Campbell JP, Kherani S, Zimmer-Galler I, Wenick A, Han I, Paulus Y, Sodhi A, Wang G, Qian J. Campochiaro PA, et al. Among authors: sodhi a. Am J Ophthalmol. 2015 Aug;160(2):313-321.e19. doi: 10.1016/j.ajo.2015.04.025. Epub 2015 Apr 20. Am J Ophthalmol. 2015. PMID: 25908486 Free PMC article. Clinical Trial.
289 results