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Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.
Guimond SE, Mycroft-West CJ, Gandhi NS, Tree JA, Le TT, Spalluto CM, Humbert MV, Buttigieg KR, Coombes N, Elmore MJ, Wand M, Nyström K, Said J, Setoh YX, Amarilla AA, Modhiran N, Sng JDJ, Chhabra M, Young PR, Rawle DJ, Lima MA, Yates EA, Karlsson R, Miller RL, Chen YH, Bagdonaite I, Yang Z, Stewart J, Nguyen D, Laidlaw S, Hammond E, Dredge K, Wilkinson TMA, Watterson D, Khromykh AA, Suhrbier A, Carroll MW, Trybala E, Bergström T, Ferro V, Skidmore MA, Turnbull JE. Guimond SE, et al. Among authors: sng jdj. ACS Cent Sci. 2022 May 25;8(5):527-545. doi: 10.1021/acscentsci.1c01293. Epub 2022 Mar 29. ACS Cent Sci. 2022. PMID: 35647275 Free PMC article.
The swan genome and transcriptome, it is not all black and white.
Karawita AC, Cheng Y, Chew KY, Challagulla A, Kraus R, Mueller RC, Tong MZW, Hulme KD, Bielefeldt-Ohmann H, Steele LE, Wu M, Sng J, Noye E, Bruxner TJ, Au GG, Lowther S, Blommaert J, Suh A, McCauley AJ, Kaur P, Dudchenko O, Aiden E, Fedrigo O, Formenti G, Mountcastle J, Chow W, Martin FJ, Ogeh DN, Thiaud-Nissen F, Howe K, Tracey A, Smith J, Kuo RI, Renfree MB, Kimura T, Sakoda Y, McDougall M, Spencer HG, Pyne M, Tolf C, Waldenström J, Jarvis ED, Baker ML, Burt DW, Short KR. Karawita AC, et al. Genome Biol. 2023 Jan 23;24(1):13. doi: 10.1186/s13059-022-02838-0. Genome Biol. 2023. PMID: 36683094 Free PMC article.
An Optimized High-Throughput Immuno-Plaque Assay for SARS-CoV-2.
Amarilla AA, Modhiran N, Setoh YX, Peng NYG, Sng JDJ, Liang B, McMillan CLD, Freney ME, Cheung STM, Chappell KJ, Khromykh AA, Young PR, Watterson D. Amarilla AA, et al. Among authors: sng jdj. Front Microbiol. 2021 Feb 12;12:625136. doi: 10.3389/fmicb.2021.625136. eCollection 2021. Front Microbiol. 2021. PMID: 33643253 Free PMC article.
Assessing the potential of unmanned aerial vehicle spraying of aqueous ozone as an outdoor disinfectant for SARS-CoV-2.
Albert S, Amarilla AA, Trollope B, Sng JDJ, Setoh YX, Deering N, Modhiran N, Weng SH, Melo MC, Hutley N, Nandy A, Furlong MJ, Young PR, Watterson D, Grinham AR, Khromykh AA. Albert S, et al. Among authors: sng jdj. Environ Res. 2021 May;196:110944. doi: 10.1016/j.envres.2021.110944. Epub 2021 Feb 26. Environ Res. 2021. PMID: 33647300 Free PMC article.
A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses.
Amarilla AA, Sng JDJ, Parry R, Deerain JM, Potter JR, Setoh YX, Rawle DJ, Le TT, Modhiran N, Wang X, Peng NYG, Torres FJ, Pyke A, Harrison JJ, Freney ME, Liang B, McMillan CLD, Cheung STM, Guevara DJDC, Hardy JM, Bettington M, Muller DA, Coulibaly F, Moore F, Hall RA, Young PR, Mackenzie JM, Hobson-Peters J, Suhrbier A, Watterson D, Khromykh AA. Amarilla AA, et al. Among authors: sng jdj. Nat Commun. 2021 Jun 8;12(1):3431. doi: 10.1038/s41467-021-23779-5. Nat Commun. 2021. PMID: 34103499 Free PMC article.
Structural analysis of 3'UTRs in insect flaviviruses reveals novel determinants of sfRNA biogenesis and provides new insights into flavivirus evolution.
Slonchak A, Parry R, Pullinger B, Sng JDJ, Wang X, Buck TF, Torres FJ, Harrison JJ, Colmant AMG, Hobson-Peters J, Hall RA, Tuplin A, Khromykh AA. Slonchak A, et al. Among authors: sng jdj. Nat Commun. 2022 Mar 11;13(1):1279. doi: 10.1038/s41467-022-28977-3. Nat Commun. 2022. PMID: 35277507 Free PMC article.
Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells.
Zhu Y, Chew KY, Wu M, Karawita AC, McCallum G, Steele LE, Yamamoto A, Labzin LI, Yarlagadda T, Khromykh AA, Wang X, Sng JDJ, Stocks CJ, Xia Y, Kollmann TR, Martino D, Joensuu M, Meunier FA, Balistreri G, Bielefeldt-Ohmann H, Bowen AC, Kicic A, Sly PD, Spann KM, Short KR. Zhu Y, et al. Among authors: sng jdj. PLoS Biol. 2022 Aug 1;20(8):e3001728. doi: 10.1371/journal.pbio.3001728. eCollection 2022 Aug. PLoS Biol. 2022. PMID: 35913989 Free PMC article.
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.
Albornoz EA, Amarilla AA, Modhiran N, Parker S, Li XX, Wijesundara DK, Aguado J, Zamora AP, McMillan CLD, Liang B, Peng NYG, Sng JDJ, Saima FT, Fung JN, Lee JD, Paramitha D, Parry R, Avumegah MS, Isaacs A, Lo MW, Miranda-Chacon Z, Bradshaw D, Salinas-Rebolledo C, Rajapakse NW, Wolvetang EJ, Munro TP, Rojas-Fernandez A, Young PR, Stacey KJ, Khromykh AA, Chappell KJ, Watterson D, Woodruff TM. Albornoz EA, et al. Among authors: sng jdj. Mol Psychiatry. 2023 Jul;28(7):2878-2893. doi: 10.1038/s41380-022-01831-0. Epub 2022 Nov 1. Mol Psychiatry. 2023. PMID: 36316366 Free PMC article.
17 results