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Epigenetic modifications of the Zfp/ZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic obesity.
Longo M, Raciti GA, Zatterale F, Parrillo L, Desiderio A, Spinelli R, Hammarstedt A, Hedjazifar S, Hoffmann JM, Nigro C, Mirra P, Fiory F, Formisano P, Miele C, Smith U, Beguinot F. Longo M, et al. Among authors: smith u. Diabetologia. 2018 Feb;61(2):369-380. doi: 10.1007/s00125-017-4471-4. Epub 2017 Oct 24. Diabetologia. 2018. PMID: 29067487 Free PMC article.
Altered PTPRD DNA methylation associates with restricted adipogenesis in healthy first-degree relatives of Type 2 diabetes subjects.
Parrillo L, Spinelli R, Longo M, Desiderio A, Mirra P, Nigro C, Fiory F, Hedjazifar S, Mutarelli M, Carissimo A, Formisano P, Miele C, Smith U, Raciti GA, Beguinot F. Parrillo L, et al. Among authors: smith u. Epigenomics. 2020 May;12(10):873-888. doi: 10.2217/epi-2019-0267. Epub 2020 Jun 2. Epigenomics. 2020. PMID: 32483983 Free article.
Adipocyte precursor cells from first degree relatives of type 2 diabetic patients feature changes in hsa-mir-23a-5p, -193a-5p, and -193b-5p and insulin-like growth factor 2 expression.
Mirra P, Desiderio A, Spinelli R, Nigro C, Longo M, Parrillo L, D'Esposito V, Carissimo A, Hedjazifar S, Smith U, Formisano P, Miele C, Raciti GA, Beguinot F. Mirra P, et al. Among authors: smith u. FASEB J. 2021 Apr;35(4):e21357. doi: 10.1096/fj.202002156RRR. FASEB J. 2021. PMID: 33710685
ZMAT3 hypomethylation contributes to early senescence of preadipocytes from healthy first-degree relatives of type 2 diabetics.
Spinelli R, Florese P, Parrillo L, Zatterale F, Longo M, D'Esposito V, Desiderio A, Nerstedt A, Gustafson B, Formisano P, Miele C, Raciti GA, Napoli R, Smith U, Beguinot F. Spinelli R, et al. Among authors: smith u. Aging Cell. 2022 Mar;21(3):e13557. doi: 10.1111/acel.13557. Epub 2022 Feb 11. Aging Cell. 2022. PMID: 35146866 Free PMC article.
Chronic hyperinsulinemia promotes human hepatocyte senescence.
Baboota RK, Spinelli R, Erlandsson MC, Brandao BB, Lino M, Yang H, Mardinoglu A, Bokarewa MI, Boucher J, Kahn CR, Smith U. Baboota RK, et al. Among authors: smith u. Mol Metab. 2022 Oct;64:101558. doi: 10.1016/j.molmet.2022.101558. Epub 2022 Jul 21. Mol Metab. 2022. PMID: 35872305 Free PMC article.
496 results