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Novel protein therapeutic joint retention strategy based on collagen-binding Avimers.
Hulme JT, D'Souza WN, McBride HJ, Yoon BP, Willee AM, Duguay A, Thomas M, Fan B, Dayao MR, Rottman JB, Merriam K, Xie J, Smith R, Alba BM, Case RB, Dang K, Montalvan A, Grinberg N, Sun H, Black RA, Gabel CA, Sims JE, Moore K, Bakker A, Li P. Hulme JT, et al. Among authors: smith r. J Orthop Res. 2018 Apr;36(4):1238-1247. doi: 10.1002/jor.23756. Epub 2017 Nov 22. J Orthop Res. 2018. PMID: 28971529 Free article.
A novel approach to improve the function of FGF21.
Smith R, Duguay A, Weiszmann J, Stanislaus S, Belouski E, Cai L, Yie J, Xu J, Gupte J, Wu X, Li Y. Smith R, et al. BioDrugs. 2013 Apr;27(2):159-66. doi: 10.1007/s40259-013-0013-x. BioDrugs. 2013. PMID: 23456652
FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein.
Smith R, Duguay A, Bakker A, Li P, Weiszmann J, Thomas MR, Alba BM, Wu X, Gupte J, Yang L, Stevens J, Hamburger A, Smith S, Chen J, Komorowski R, Moore KW, Véniant MM, Li Y. Smith R, et al. Among authors: smith s. PLoS One. 2013 Apr 22;8(4):e61432. doi: 10.1371/journal.pone.0061432. Print 2013. PLoS One. 2013. PMID: 23630589 Free PMC article.
Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies.
Mock M, Jacobitz AW, Langmead CJ, Sudom A, Yoo D, Humphreys SC, Alday M, Alekseychyk L, Angell N, Bi V, Catterall H, Chen CC, Chou HT, Conner KP, Cook KD, Correia AR, Dykstra A, Ghimire-Rijal S, Graham K, Grandsard P, Huh J, Hui JO, Jain M, Jann V, Jia L, Johnstone S, Khanal N, Kolvenbach C, Narhi L, Padaki R, Pelegri-O'Day EM, Qi W, Razinkov V, Rice AJ, Smith R, Spahr C, Stevens J, Sun Y, Thomas VA, van Driesche S, Vernon R, Wagner V, Walker KW, Wei Y, Winters D, Yang M, Campuzano IDG. Mock M, et al. Among authors: smith r. MAbs. 2023 Jan-Dec;15(1):2256745. doi: 10.1080/19420862.2023.2256745. MAbs. 2023. PMID: 37698932 Free PMC article.
Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice.
Liu S, Humphreys SC, Cook KD, Conner KP, Correia AR, Jacobitz AW, Yang M, Primack R, Soto M, Padaki R, Lubomirski M, Smith R, Mock M, Thomas VA. Liu S, et al. Among authors: smith r. MAbs. 2023 Jan-Dec;15(1):2263926. doi: 10.1080/19420862.2023.2263926. Epub 2023 Oct 12. MAbs. 2023. PMID: 37824334 Free PMC article.
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