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Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance.
Naeem A, Utro F, Wang Q, Cha J, Vihinen M, Martindale S, Zhou Y, Ren Y, Tyekucheva S, Kim AS, Fernandes SM, Saksena G, Rhrissorrakrai K, Levovitz C, Danysh BP, Slowik K, Jacobs RA, Davids MS, Lederer JA, Zain R, Smith CIE, Leshchiner I, Parida L, Getz G, Brown JR. Naeem A, et al. Among authors: smith cie. Blood Adv. 2023 May 9;7(9):1929-1943. doi: 10.1182/bloodadvances.2022008447. Blood Adv. 2023. PMID: 36287227 Free PMC article.
Tec homology (TH) adjacent to the PH domain.
Vihinen M, Nilsson L, Smith CI. Vihinen M, et al. FEBS Lett. 1994 Aug 22;350(2-3):263-5. doi: 10.1016/0014-5793(94)00783-7. FEBS Lett. 1994. PMID: 8070576 Free article.
Interactions between SH2 and SH3 domains.
Vihinen M, Smith CI. Vihinen M, et al. Biochem Biophys Res Commun. 1998 Jan 14;242(2):351-6. doi: 10.1006/bbrc.1997.7909. Biochem Biophys Res Commun. 1998. PMID: 9446798
284 results