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Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia.
Morrow MR, Batchuluun B, Wu J, Ahmadi E, Leroux JM, Mohammadi-Shemirani P, Desjardins EM, Wang Z, Tsakiridis EE, Lavoie DCT, Reihani A, Smith BK, Kwiecien JM, Lally JSV, Nero TL, Parker MW, Ask K, Scott JW, Jiang L, Paré G, Pinkosky SL, Steinberg GR. Morrow MR, et al. Among authors: smith bk. Cell Metab. 2022 Jun 7;34(6):919-936.e8. doi: 10.1016/j.cmet.2022.05.004. Cell Metab. 2022. PMID: 35675800 Free article.
AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice.
O'Neill HM, Lally JS, Galic S, Thomas M, Azizi PD, Fullerton MD, Smith BK, Pulinilkunnil T, Chen Z, Samaan MC, Jorgensen SB, Dyck JR, Holloway GP, Hawke TJ, van Denderen BJ, Kemp BE, Steinberg GR. O'Neill HM, et al. Among authors: smith bk. Diabetologia. 2014 Aug;57(8):1693-702. doi: 10.1007/s00125-014-3273-1. Epub 2014 Jun 10. Diabetologia. 2014. PMID: 24913514
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.
Mottillo EP, Desjardins EM, Crane JD, Smith BK, Green AE, Ducommun S, Henriksen TI, Rebalka IA, Razi A, Sakamoto K, Scheele C, Kemp BE, Hawke TJ, Ortega J, Granneman JG, Steinberg GR. Mottillo EP, et al. Among authors: smith bk. Cell Metab. 2016 Jul 12;24(1):118-29. doi: 10.1016/j.cmet.2016.06.006. Cell Metab. 2016. PMID: 27411013 Free PMC article.
Treatment of nonalcoholic fatty liver disease: role of AMPK.
Smith BK, Marcinko K, Desjardins EM, Lally JS, Ford RJ, Steinberg GR. Smith BK, et al. Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E730-E740. doi: 10.1152/ajpendo.00225.2016. Epub 2016 Aug 30. Am J Physiol Endocrinol Metab. 2016. PMID: 27577854 Free article. Review.
281 results