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Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration.
Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. Felszeghy S, et al. Among authors: smedowski a. Redox Biol. 2019 Jan;20:1-12. doi: 10.1016/j.redox.2018.09.011. Epub 2018 Sep 14. Redox Biol. 2019. PMID: 30253279 Free PMC article.
A novel proteotoxic stress associated mechanism for macular corneal dystrophy.
Kaarniranta K, Szalai E, Smedowski A, Hegyi Z, Kivinen N, Viiri J, Wowra B, Dobrowolski D, Módis L Jr, Berta A, Wylegala E, Felszeghy S. Kaarniranta K, et al. Among authors: smedowski a. Histol Histopathol. 2015 Aug;30(8):921-30. doi: 10.14670/HH-11-588. Epub 2015 Jan 19. Histol Histopathol. 2015. PMID: 25597745
Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells - A possible sign of endogenous neuroprotection failure.
Smedowski A, Liu X, Podracka L, Akhtar S, Trzeciecka A, Pietrucha-Dutczak M, Lewin-Kowalik J, Urtti A, Ruponen M, Kaarniranta K, Varjosalo M, Amadio M. Smedowski A, et al. Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):296-306. doi: 10.1016/j.bbadis.2017.10.030. Epub 2017 Oct 28. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 29107807 Free article.
Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways.
Marchesi N, Thongon N, Pascale A, Provenzani A, Koskela A, Korhonen E, Smedowski A, Govoni S, Kauppinen A, Kaarniranta K, Amadio M. Marchesi N, et al. Among authors: smedowski a. Oxid Med Cell Longev. 2018 Feb 8;2018:4956080. doi: 10.1155/2018/4956080. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 29576851 Free PMC article.
Molecular Mechanisms Underlying Age-Related Ocular Diseases.
Amadio M, Kaarniranta K, Xu H, Smedowski A, Ferrington DA. Amadio M, et al. Among authors: smedowski a. Oxid Med Cell Longev. 2018 May 21;2018:8476164. doi: 10.1155/2018/8476164. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 29951167 Free PMC article. No abstract available.
34 results