Slusher BS - Search Results

1

A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis.

Peters DE, Norris LD, Tenora L, Šnajdr I, Ponti AK, Zhu X, Sakamoto S, Veeravalli V, Pradhan M, Alt J, Thomas AG, Majer P, Rais R, McDonald C, Slusher BS. Peters DE, et al. Among authors: slusher bs. Sci Transl Med. 2023 Aug 9;15(708):eabn7491. doi: 10.1126/scitranslmed.abn7491. Epub 2023 Aug 9. Sci Transl Med. 2023. PMID: 37556558 Free PMC article.

2

Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhibition.

Thomas AG, Olkowski JL, Vornov JJ, Slusher BS. Thomas AG, et al. Among authors: slusher bs. Brain Res. 1999 Oct 2;843(1-2):48-52. doi: 10.1016/s0006-8993(99)01879-x. Brain Res. 1999. PMID: 10528109

3

Neuroprotection afforded by NAAG and NAALADase inhibition requires glial cells and metabotropic glutamate receptor activation.

Thomas AG, Olkowski JL, Slusher BS. Thomas AG, et al. Among authors: slusher bs. Eur J Pharmacol. 2001 Aug 24;426(1-2):35-8. doi: 10.1016/s0014-2999(01)01198-0. Eur J Pharmacol. 2001. PMID: 11525768

4

Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta.

Thomas AG, Liu W, Olkowski JL, Tang Z, Lin Q, Lu XC, Slusher BS. Thomas AG, et al. Among authors: slusher bs. Eur J Pharmacol. 2001 Oct 26;430(1):33-40. doi: 10.1016/s0014-2999(01)01239-0. Eur J Pharmacol. 2001. PMID: 11698060

5

Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II.

Barinka C, Rinnová M, Sácha P, Rojas C, Majer P, Slusher BS, Konvalinka J. Barinka C, et al. Among authors: slusher bs. J Neurochem. 2002 Feb;80(3):477-87. doi: 10.1046/j.0022-3042.2001.00715.x. J Neurochem. 2002. PMID: 11905994 Free article.

6

Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate.

Strísovský K, Jirásková J, Barinka C, Majer P, Rojas C, Slusher BS, Konvalinka J. Strísovský K, et al. Among authors: slusher bs. FEBS Lett. 2003 Jan 30;535(1-3):44-8. doi: 10.1016/s0014-5793(02)03855-3. FEBS Lett. 2003. PMID: 12560076 Free article.

7

Glutamate carboxypeptidase II inhibition as a novel therapeutic target.

Rojas C, Thomas AG, Majer P, Tsukamoto T, Lu XM, Vornov JJ, Wozniak KM, Slusher BS. Rojas C, et al. Among authors: slusher bs. Adv Exp Med Biol. 2003;524:205-13. doi: 10.1007/0-306-47920-6_25. Adv Exp Med Biol. 2003. PMID: 12675241 Review. No abstract available.

8

Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.

Majer P, Jackson PF, Delahanty G, Grella BS, Ko YS, Li W, Liu Q, Maclin KM, Poláková J, Shaffer KA, Stoermer D, Vitharana D, Wang EY, Zakrzewski A, Rojas C, Slusher BS, Wozniak KM, Burak E, Limsakun T, Tsukamoto T. Majer P, et al. Among authors: slusher bs. J Med Chem. 2003 May 8;46(10):1989-96. doi: 10.1021/jm020515w. J Med Chem. 2003. PMID: 12723961

9

Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II.

Stoermer D, Liu Q, Hall MR, Flanary JM, Thomas AG, Rojas C, Slusher BS, Tsukamoto T. Stoermer D, et al. Among authors: slusher bs. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2097-100. doi: 10.1016/s0960-894x(03)00407-4. Bioorg Med Chem Lett. 2003. PMID: 12798312

10

NAALADase inhibition protects motor neurons against chronic glutamate toxicity.

Thomas AG, Corse AM, Coccia CF, Bilak MM, Rothstein JD, Slusher BS. Thomas AG, et al. Among authors: slusher bs. Eur J Pharmacol. 2003 Jun 27;471(3):177-84. doi: 10.1016/s0014-2999(03)01832-6. Eur J Pharmacol. 2003. PMID: 12826236

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