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Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.
Aleyasin H, Karuppagounder SS, Kumar A, Sleiman S, Basso M, Ma T, Siddiq A, Chinta SJ, Brochier C, Langley B, Haskew-Layton R, Bane SL, Riggins GJ, Gazaryan I, Starkov AA, Andersen JK, Ratan RR. Aleyasin H, et al. Among authors: sleiman s. Antioxid Redox Signal. 2015 Jan 10;22(2):121-34. doi: 10.1089/ars.2013.5595. Antioxid Redox Signal. 2015. PMID: 24766300 Free PMC article.
Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.
Speer RE, Karuppagounder SS, Basso M, Sleiman SF, Kumar A, Brand D, Smirnova N, Gazaryan I, Khim SJ, Ratan RR. Speer RE, et al. Among authors: sleiman sf. Free Radic Biol Med. 2013 Sep;62:26-36. doi: 10.1016/j.freeradbiomed.2013.01.026. Epub 2013 Jan 31. Free Radic Biol Med. 2013. PMID: 23376032 Free PMC article. Review.
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.
McConoughey SJ, Basso M, Niatsetskaya ZV, Sleiman SF, Smirnova NA, Langley BC, Mahishi L, Cooper AJ, Antonyak MA, Cerione RA, Li B, Starkov A, Chaturvedi RK, Beal MF, Coppola G, Geschwind DH, Ryu H, Xia L, Iismaa SE, Pallos J, Pasternack R, Hils M, Fan J, Raymond LA, Marsh JL, Thompson LM, Ratan RR. McConoughey SJ, et al. EMBO Mol Med. 2010 Sep;2(9):349-70. doi: 10.1002/emmm.201000084. EMBO Mol Med. 2010. PMID: 20665636 Free PMC article.
53 results