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TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment.
Wolczyk M, Serwa R, Kominek A, Klejman A, Milek J, Chwałek M, Turos-Korgul L, Charzyńska A, Dabrowski M, Dziembowska M, Skorski T, Piwocka K, Podszywalow-Bartnicka P. Wolczyk M, et al. Among authors: skorski t. iScience. 2023 Mar 31;26(4):106543. doi: 10.1016/j.isci.2023.106543. eCollection 2023 Apr 21. iScience. 2023. PMID: 37123244 Free PMC article.
Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours.
Barszczewska-Pietraszek G, Drzewiecka M, Czarny P, Skorski T, Śliwiński T. Barszczewska-Pietraszek G, et al. Among authors: skorski t. Int J Mol Sci. 2022 Dec 24;24(1):319. doi: 10.3390/ijms24010319. Int J Mol Sci. 2022. PMID: 36613762 Free PMC article. Review.
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors.
Fried W, Tyagi M, Minakhin L, Chandramouly G, Tredinnick T, Ramanjulu M, Auerbacher W, Calbert M, Rusanov T, Hoang T, Borisonnik N, Betsch R, Krais JJ, Wang Y, Vekariya UM, Gordon J, Morton G, Kent T, Skorski T, Johnson N, Childers W, Chen XS, Pomerantz RT. Fried W, et al. Among authors: skorski t. Nat Commun. 2024 Apr 5;15(1):2862. doi: 10.1038/s41467-024-46593-1. Nat Commun. 2024. PMID: 38580648 Free PMC article.
Clonal medicine targeting DNA damage response eradicates leukemia.
Toma MM, Karami A, Nieborowska-Skorska M, Chirtala KN, Pepek M, Hadzijusufovic E, Stoklosa T, Valent P, Skorski T. Toma MM, et al. Among authors: skorski t. Leukemia. 2024 Mar;38(3):671-675. doi: 10.1038/s41375-024-02138-5. Epub 2024 Jan 16. Leukemia. 2024. PMID: 38228681 Free PMC article. No abstract available.
4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.
Calbert ML, Chandramouly G, Adams CM, Saez-Ayala M, Kent T, Tyagi M, Ayyadevara VSSA, Wang Y, Krais JJ, Gordon J, Atkins J, Toma MM, Betzi S, Boghossian AS, Rees MG, Ronan MM, Roth JA, Goldman AR, Gorman N, Mitra R, Childers WE, Graña X, Skorski T, Johnson N, Hurtz C, Morelli X, Eischen CM, Pomerantz RT. Calbert ML, et al. Among authors: skorski t. Mol Cancer Ther. 2024 May 2;23(5):683-699. doi: 10.1158/1535-7163.MCT-23-0487. Mol Cancer Ther. 2024. PMID: 38064712
R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts.
Liu ZS, Sinha S, Bannister M, Song A, Arriaga-Gomez E, McKeeken AJ, Bonner EA, Hanson BK, Sarchi M, Takashima K, Zong D, Corral VM, Nguyen E, Yoo J, Chiraphapphaiboon W, Leibson C, McMahon MC, Rai S, Swisher EM, Sachs Z, Chatla S, Stirewalt DL, Deeg HJ, Skorski T, Papapetrou EP, Walter MJ, Graubert TA, Doulatov S, Lee SC, Nguyen HD. Liu ZS, et al. Among authors: skorski t. Cancer Res. 2024 Feb 15;84(4):577-597. doi: 10.1158/0008-5472.CAN-23-3239. Cancer Res. 2024. PMID: 37967363
206 results