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HBK-14 and HBK-15, triple 5-HT1A, 5-HT7 and 5-HT3 antagonists with potent antidepressant- and anxiolytic-like properties, increase seizure threshold in various seizure tests in mice.
Pytka K, Socała K, Rapacz A, Nieoczym D, Pieróg M, Gryboś A, Siwek A, Waszkielewicz A, Wlaź P. Pytka K, et al. Among authors: siwek a. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):378-385. doi: 10.1016/j.pnpbp.2017.07.013. Epub 2017 Jul 17. Prog Neuropsychopharmacol Biol Psychiatry. 2017. PMID: 28729118
Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands.
Łażewska D, Kaleta M, Schwed JS, Karcz T, Mogilski S, Latacz G, Olejarz A, Siwek A, Kubacka M, Lubelska A, Honkisz E, Handzlik J, Filipek B, Stark H, Kieć-Kononowicz K. Łażewska D, et al. Among authors: siwek a. Bioorg Med Chem. 2017 Oct 15;25(20):5341-5354. doi: 10.1016/j.bmc.2017.07.058. Epub 2017 Jul 29. Bioorg Med Chem. 2017. PMID: 28797771
Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione - a novel anticonvulsant drug candidate.
Kaproń B, Łuszczki J, Paneth A, Wujec M, Siwek A, Karcz T, Mordyl B, Głuch-Lutwin M, Gryboś A, Nowak G, Pająk K, Jóźwiak K, Tomczykowski A, Plech T. Kaproń B, et al. Among authors: siwek a. Int J Med Sci. 2017 Jul 18;14(8):741-749. doi: 10.7150/ijms.20001. eCollection 2017. Int J Med Sci. 2017. PMID: 28824309 Free PMC article.
Study on the effect of EMD386088, a 5-HT6 receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats.
Jastrzębska-Więsek M, Siwek A, Partyka A, Kołaczkowski M, Walczak M, Smolik M, Latacz G, Kieć-Kononowicz K, Wesołowska A. Jastrzębska-Więsek M, et al. Among authors: siwek a. Naunyn Schmiedebergs Arch Pharmacol. 2018 Jan;391(1):37-49. doi: 10.1007/s00210-017-1431-y. Epub 2017 Oct 27. Naunyn Schmiedebergs Arch Pharmacol. 2018. PMID: 29079874 Free PMC article.
190 results