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Urolithin A attenuates severity of chronic pancreatitis associated with continued alcohol intake by inhibiting PI3K/AKT/mTOR signaling.
Mehra S, Srinivasan S, Singh S, Zhou Z, Garrido V, Silva IC, Totiger TM, Dosch AR, Dai X, Dawra RK, Jala VR, Shi C, Datta J, VanSaun M, Merchant N, Nagathihalli N. Mehra S, et al. Among authors: singh s. Am J Physiol Gastrointest Liver Physiol. 2022 Oct 1;323(4):G375-G386. doi: 10.1152/ajpgi.00159.2022. Epub 2022 Sep 13. Am J Physiol Gastrointest Liver Physiol. 2022. PMID: 36098401 Free PMC article.
Interleukin-1 signaling in solid organ malignancies.
Dosch AR, Singh S, Nagathihalli NS, Datta J, Merchant NB. Dosch AR, et al. Among authors: singh s. Biochim Biophys Acta Rev Cancer. 2022 Jan;1877(1):188670. doi: 10.1016/j.bbcan.2021.188670. Epub 2021 Dec 16. Biochim Biophys Acta Rev Cancer. 2022. PMID: 34923027 Review.
Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer.
Datta J, Bianchi A, De Castro Silva I, Deshpande NU, Cao LL, Mehra S, Singh S, Rafie C, Sun X, Chen X, Dai X, Colaprico A, Sharma P, Dosch AR, Pillai A, Hosein PJ, Nagathihalli NS, Komanduri KV, Wilson JM, Ban Y, Merchant NB. Datta J, et al. Among authors: singh s. Oncogene. 2022 Jul;41(28):3640-3654. doi: 10.1038/s41388-022-02368-w. Epub 2022 Jun 14. Oncogene. 2022. PMID: 35701533
Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer.
Datta J, Dai X, Bianchi A, De Castro Silva I, Mehra S, Garrido VT, Lamichhane P, Singh SP, Zhou Z, Dosch AR, Messaggio F, Ban Y, Umland O, Hosein PJ, Nagathihalli NS, Merchant NB. Datta J, et al. Among authors: singh sp. Gastroenterology. 2022 Dec;163(6):1593-1612. doi: 10.1053/j.gastro.2022.07.076. Epub 2022 Aug 7. Gastroenterology. 2022. PMID: 35948109 Free PMC article.
Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer.
Bianchi A, De Castro Silva I, Deshpande NU, Singh S, Mehra S, Garrido VT, Guo X, Nivelo LA, Kolonias DS, Saigh SJ, Wieder E, Rafie CI, Dosch AR, Zhou Z, Umland O, Amirian H, Ogobuiro IC, Zhang J, Ban Y, Shiau C, Nagathihalli NS, Montgomery EA, Hwang WL, Brambilla R, Komanduri K, Villarino AV, Toska E, Stanger BZ, Gabrilovich DI, Merchant NB, Datta J. Bianchi A, et al. Among authors: singh s. Cancer Discov. 2023 Jun 2;13(6):1428-1453. doi: 10.1158/2159-8290.CD-22-1046. Cancer Discov. 2023. PMID: 36946782 Free PMC article.
Remodeling of Stromal Immune Microenvironment by Urolithin A Improves Survival with Immune Checkpoint Blockade in Pancreatic Cancer.
Mehra S, Garrido VT, Dosch AR, Lamichhane P, Srinivasan S, Singh SP, Zhou Z, De Castro Silva I, Joshi C, Ban Y, Datta J, Gilboa E, Merchant NB, Nagathihalli NS. Mehra S, et al. Among authors: singh sp. Cancer Res Commun. 2023 Jul 12;3(7):1224-1236. doi: 10.1158/2767-9764.CRC-22-0329. eCollection 2023 Jul. Cancer Res Commun. 2023. PMID: 37448553 Free PMC article.
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