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Sphingolipids as targets for treatment of fungal infections.
Rollin-Pinheiro R, Singh A, Barreto-Bergter E, Del Poeta M. Rollin-Pinheiro R, et al. Among authors: singh a. Future Med Chem. 2016 Aug;8(12):1469-84. doi: 10.4155/fmc-2016-0053. Epub 2016 Aug 9. Future Med Chem. 2016. PMID: 27502288 Free PMC article. Review.
Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids.
Mor V, Rella A, Farnoud AM, Singh A, Munshi M, Bryan A, Naseem S, Konopka JB, Ojima I, Bullesbach E, Ashbaugh A, Linke MJ, Cushion M, Collins M, Ananthula HK, Sallans L, Desai PB, Wiederhold NP, Fothergill AW, Kirkpatrick WR, Patterson T, Wong LH, Sinha S, Giaever G, Nislow C, Flaherty P, Pan X, Cesar GV, de Melo Tavares P, Frases S, Miranda K, Rodrigues ML, Luberto C, Nimrichter L, Del Poeta M. Mor V, et al. Among authors: singh a. mBio. 2015 Jun 23;6(3):e00647. doi: 10.1128/mBio.00647-15. mBio. 2015. PMID: 26106079 Free PMC article.
Functional characterization of the Aspergillus nidulans glucosylceramide pathway reveals that LCB Δ8-desaturation and C9-methylation are relevant to filamentous growth, lipid raft localization and Psd1 defensin activity.
Fernandes CM, de Castro PA, Singh A, Fonseca FL, Pereira MD, Vila TV, Atella GC, Rozental S, Savoldi M, Del Poeta M, Goldman GH, Kurtenbach E. Fernandes CM, et al. Among authors: singh a. Mol Microbiol. 2016 Nov;102(3):488-505. doi: 10.1111/mmi.13474. Epub 2016 Aug 25. Mol Microbiol. 2016. PMID: 27479571 Free PMC article.
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