Singaraja R - Search Results

1

Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity.

Huang K, Sanders S, Singaraja R, Orban P, Cijsouw T, Arstikaitis P, Yanai A, Hayden MR, El-Husseini A. Huang K, et al. Among authors: singaraja r. FASEB J. 2009 Aug;23(8):2605-15. doi: 10.1096/fj.08-127399. Epub 2009 Mar 19. FASEB J. 2009. PMID: 19299482 Free PMC article.

2

Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.

Huang K, Yanai A, Kang R, Arstikaitis P, Singaraja RR, Metzler M, Mullard A, Haigh B, Gauthier-Campbell C, Gutekunst CA, Hayden MR, El-Husseini A. Huang K, et al. Among authors: singaraja rr. Neuron. 2004 Dec 16;44(6):977-86. doi: 10.1016/j.neuron.2004.11.027. Neuron. 2004. PMID: 15603740 Free article.

3

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.

Yanai A, Huang K, Kang R, Singaraja RR, Arstikaitis P, Gan L, Orban PC, Mullard A, Cowan CM, Raymond LA, Drisdel RC, Green WN, Ravikumar B, Rubinsztein DC, El-Husseini A, Hayden MR. Yanai A, et al. Among authors: singaraja rr. Nat Neurosci. 2006 Jun;9(6):824-31. doi: 10.1038/nn1702. Epub 2006 May 14. Nat Neurosci. 2006. PMID: 16699508 Free PMC article.

4

Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function.

Singaraja RR, Kang MH, Vaid K, Sanders SS, Vilas GL, Arstikaitis P, Coutinho J, Drisdel RC, El-Husseini Ael D, Green WN, Berthiaume L, Hayden MR. Singaraja RR, et al. Circ Res. 2009 Jul 17;105(2):138-47. doi: 10.1161/CIRCRESAHA.108.193011. Epub 2009 Jun 25. Circ Res. 2009. PMID: 19556522

5

Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.

Huang K, Sanders SS, Kang R, Carroll JB, Sutton L, Wan J, Singaraja R, Young FB, Liu L, El-Husseini A, Davis NG, Hayden MR. Huang K, et al. Among authors: singaraja r. Hum Mol Genet. 2011 Sep 1;20(17):3356-65. doi: 10.1093/hmg/ddr242. Epub 2011 Jun 2. Hum Mol Genet. 2011. PMID: 21636527 Free PMC article.

6

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.

Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR. Singaraja RR, et al. Hum Mol Genet. 2002 Nov 1;11(23):2815-28. doi: 10.1093/hmg/11.23.2815. Hum Mol Genet. 2002. PMID: 12393793

7

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo.

Warby SC, Chan EY, Metzler M, Gan L, Singaraja RR, Crocker SF, Robertson HA, Hayden MR. Warby SC, et al. Among authors: singaraja rr. Hum Mol Genet. 2005 Jun 1;14(11):1569-77. doi: 10.1093/hmg/ddi165. Epub 2005 Apr 20. Hum Mol Genet. 2005. PMID: 15843398

8

Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments.

Warby SC, Doty CN, Graham RK, Shively J, Singaraja RR, Hayden MR. Warby SC, et al. Among authors: singaraja rr. Mol Cell Neurosci. 2009 Feb;40(2):121-7. doi: 10.1016/j.mcn.2008.09.007. Epub 2008 Oct 18. Mol Cell Neurosci. 2009. PMID: 18992820

9

Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

Singaraja RR, Huang K, Sanders SS, Milnerwood AJ, Hines R, Lerch JP, Franciosi S, Drisdel RC, Vaid K, Young FB, Doty C, Wan J, Bissada N, Henkelman RM, Green WN, Davis NG, Raymond LA, Hayden MR. Singaraja RR, et al. Hum Mol Genet. 2011 Oct 15;20(20):3899-909. doi: 10.1093/hmg/ddr308. Epub 2011 Jul 20. Hum Mol Genet. 2011. PMID: 21775500 Free PMC article.

10

Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice.

Young FB, Franciosi S, Spreeuw A, Deng Y, Sanders S, Tam NC, Huang K, Singaraja RR, Zhang W, Bissada N, Kay C, Hayden MR. Young FB, et al. Among authors: singaraja rr. PLoS One. 2012;7(5):e36315. doi: 10.1371/journal.pone.0036315. Epub 2012 May 23. PLoS One. 2012. PMID: 22649491 Free PMC article.

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