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Suppressor CD4+ T cells expressing HLA-G are expanded in the peripheral blood from patients with acute decompensation of cirrhosis.
Khamri W, Gudd C, Liu T, Nathwani R, Krasniqi M, Azam S, Barbera T, Trovato FM, Possamai L, Triantafyllou E, Seoane RC, Lebosse F, Singanayagam A, Kumar N, Bernsmeier C, Mukherjee S, McPhail M, Weston CJ, Antoniades CG, Thursz MR. Khamri W, et al. Among authors: singanayagam a. Gut. 2022 Jun;71(6):1192-1202. doi: 10.1136/gutjnl-2021-324071. Epub 2021 Aug 3. Gut. 2022. PMID: 34344786 Free PMC article.
Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK.
Bernsmeier C, Pop OT, Singanayagam A, Triantafyllou E, Patel VC, Weston CJ, Curbishley S, Sadiq F, Vergis N, Khamri W, Bernal W, Auzinger G, Heneghan M, Ma Y, Jassem W, Heaton ND, Adams DH, Quaglia A, Thursz MR, Wendon J, Antoniades CG. Bernsmeier C, et al. Among authors: singanayagam a. Gastroenterology. 2015 Mar;148(3):603-615.e14. doi: 10.1053/j.gastro.2014.11.045. Epub 2014 Dec 3. Gastroenterology. 2015. PMID: 25479139 Free article.
Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure.
Khamri W, Abeles RD, Hou TZ, Anderson AE, El-Masry A, Triantafyllou E, Bernsmeier C, Larsen FS, Singanayagam A, Kudo N, Possamai LA, Lebosse F, Auzinger G, Bernal W, Willars C, Weston CJ, Lombardi G, Wendon J, Thursz M, Antoniades CG. Khamri W, et al. Among authors: singanayagam a. Gastroenterology. 2017 Jul;153(1):263-276.e8. doi: 10.1053/j.gastro.2017.03.023. Epub 2017 Mar 28. Gastroenterology. 2017. PMID: 28363639 Free PMC article.
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure.
Triantafyllou E, Pop OT, Possamai LA, Wilhelm A, Liaskou E, Singanayagam A, Bernsmeier C, Khamri W, Petts G, Dargue R, Davies SP, Tickle J, Yuksel M, Patel VC, Abeles RD, Stamataki Z, Curbishley SM, Ma Y, Wilson ID, Coen M, Woollard KJ, Quaglia A, Wendon J, Thursz MR, Adams DH, Weston CJ, Antoniades CG. Triantafyllou E, et al. Among authors: singanayagam a. Gut. 2018 Feb;67(2):333-347. doi: 10.1136/gutjnl-2016-313615. Epub 2017 Apr 27. Gut. 2018. PMID: 28450389 Free PMC article.
CD14+ CD15- HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure.
Bernsmeier C, Triantafyllou E, Brenig R, Lebosse FJ, Singanayagam A, Patel VC, Pop OT, Khamri W, Nathwani R, Tidswell R, Weston CJ, Adams DH, Thursz MR, Wendon JA, Antoniades CG. Bernsmeier C, et al. Among authors: singanayagam a. Gut. 2018 Jun;67(6):1155-1167. doi: 10.1136/gutjnl-2017-314184. Epub 2017 Jun 7. Gut. 2018. PMID: 28592438 Free PMC article.
CD8+T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunction.
Lebossé F, Gudd C, Tunc E, Singanayagam A, Nathwani R, Triantafyllou E, Pop O, Kumar N, Mukherjee S, Hou TZ, Quaglia A, Zoulim F, Wendon J, Dhar A, Thursz M, Antoniades CG, Khamri W. Lebossé F, et al. Among authors: singanayagam a. EBioMedicine. 2019 Nov;49:258-268. doi: 10.1016/j.ebiom.2019.10.011. Epub 2019 Oct 31. EBioMedicine. 2019. PMID: 31678004 Free PMC article.
Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis.
Brenig R, Pop OT, Triantafyllou E, Geng A, Singanayagam A, Perez-Shibayama C, Besse L, Cupovic J, Künzler P, Boldanova T, Brand S, Semela D, Duong FH, Weston CJ, Ludewig B, Heim MH, Wendon J, Antoniades CG, Bernsmeier C. Brenig R, et al. Among authors: singanayagam a. Life Sci Alliance. 2019 Dec 10;3(1):e201900465. doi: 10.26508/lsa.201900465. Print 2020 Jan. Life Sci Alliance. 2019. PMID: 31822557 Free PMC article.
148 results