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Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways.
Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Ince PG; Medical Research Council Cognitive Function and Ageing Study Neuropathology Group. Simpson JE, et al. Stroke. 2009 Feb;40(2):369-75. doi: 10.1161/STROKEAHA.108.529214. Epub 2008 Dec 24. Stroke. 2009. PMID: 19109541
Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype.
Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE, Brayne C, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Simpson JE, et al. Neurobiol Aging. 2011 Oct;32(10):1795-807. doi: 10.1016/j.neurobiolaging.2011.04.013. Epub 2011 Jun 25. Neurobiol Aging. 2011. PMID: 21705112
Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain.
Garwood C, Faizullabhoy A, Wharton SB, Ince PG, Heath PR, Shaw PJ, Baxter L, Gelsthorpe C, Forster G, Matthews FE, Brayne C, Simpson JE; MRC Cognitive Function and Ageing Neuropathology Study Group. Garwood C, et al. Among authors: simpson je. Neuropathol Appl Neurobiol. 2013 Dec;39(7):788-99. doi: 10.1111/nan.12033. Neuropathol Appl Neurobiol. 2013. PMID: 23421725
Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds.
Janaway BM, Simpson JE, Hoggard N, Highley JR, Forster G, Drew D, Gebril OH, Matthews FE, Brayne C, Wharton SB, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study. Janaway BM, et al. Among authors: simpson je. Neuropathol Appl Neurobiol. 2014 Apr;40(3):258-69. doi: 10.1111/nan.12062. Neuropathol Appl Neurobiol. 2014. PMID: 23678850 Free PMC article.
Alpha-synuclein mRNA expression in oligodendrocytes in MSA.
Asi YT, Simpson JE, Heath PR, Wharton SB, Lees AJ, Revesz T, Houlden H, Holton JL. Asi YT, et al. Among authors: simpson je. Glia. 2014 Jun;62(6):964-70. doi: 10.1002/glia.22653. Epub 2014 Mar 3. Glia. 2014. PMID: 24590631 Free PMC article.
Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain.
Al-Mashhadi S, Simpson JE, Heath PR, Dickman M, Forster G, Matthews FE, Brayne C, Ince PG, Wharton SB; Medical Research Council Cognitive Function and Ageing Study. Al-Mashhadi S, et al. Among authors: simpson je. Brain Pathol. 2015 Sep;25(5):565-74. doi: 10.1111/bpa.12216. Epub 2014 Nov 20. Brain Pathol. 2015. PMID: 25311358 Free PMC article.
A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort.
Simpson JE, Ince PG, Matthews FE, Shaw PJ, Heath PR, Brayne C, Garwood C, Higginbottom A, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Simpson JE, et al. Neuropathol Appl Neurobiol. 2015 Jun;41(4):483-96. doi: 10.1111/nan.12202. Epub 2015 Apr 23. Neuropathol Appl Neurobiol. 2015. PMID: 25443110 Free PMC article.
Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.
Simpson JE, Ince PG, Minett T, Matthews FE, Heath PR, Shaw PJ, Goodall E, Garwood CJ, Ratcliffe LE, Brayne C, Rattray M, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Simpson JE, et al. Neuropathol Appl Neurobiol. 2016 Feb;42(2):167-79. doi: 10.1111/nan.12252. Epub 2015 Jul 7. Neuropathol Appl Neurobiol. 2016. PMID: 26095650 Free PMC article.
122 results