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Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort.
Carapito R, Li R, Helms J, Carapito C, Gujja S, Rolli V, Guimaraes R, Malagon-Lopez J, Spinnhirny P, Lederle A, Mohseninia R, Hirschler A, Muller L, Bastard P, Gervais A, Zhang Q, Danion F, Ruch Y, Schenck M, Collange O, Chamaraux-Tran TN, Molitor A, Pichot A, Bernard A, Tahar O, Bibi-Triki S, Wu H, Paul N, Mayeur S, Larnicol A, Laumond G, Frappier J, Schmidt S, Hanauer A, Macquin C, Stemmelen T, Simons M, Mariette X, Hermine O, Fafi-Kremer S, Goichot B, Drenou B, Kuteifan K, Pottecher J, Mertes PM, Kailasan S, Aman MJ, Pin E, Nilsson P, Thomas A, Viari A, Sanlaville D, Schneider F, Sibilia J, Tharaux PL, Casanova JL, Hansmann Y, Lidar D, Radosavljevic M, Gulcher JR, Meziani F, Moog C, Chittenden TW, Bahram S. Carapito R, et al. Among authors: simons m. Sci Transl Med. 2022 Jan 19;14(628):eabj7521. doi: 10.1126/scitranslmed.abj7521. Epub 2022 Jan 19. Sci Transl Med. 2022. PMID: 34698500 Free article.
Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium.
Ricard N, Scott RP, Booth CJ, Velazquez H, Cilfone NA, Baylon JL, Gulcher JR, Quaggin SE, Chittenden TW, Simons M. Ricard N, et al. Among authors: simons m. J Exp Med. 2019 Aug 5;216(8):1874-1890. doi: 10.1084/jem.20182151. Epub 2019 Jun 13. J Exp Med. 2019. PMID: 31196980 Free PMC article.
Resilience, disease and the age of single cell science.
Simons M, Chen PY, Chittenden TW. Simons M, et al. Aging (Albany NY). 2020 Feb 10;12(3):2028-2029. doi: 10.18632/aging.102850. Epub 2020 Feb 10. Aging (Albany NY). 2020. PMID: 32039835 Free PMC article. No abstract available.
In silico phenotype projection of endothelial ERK1/2 signaling.
Simons M, Gulcher JR, Chittenden TW. Simons M, et al. Aging (Albany NY). 2020 Jun 12;12(11):10001-10003. doi: 10.18632/aging.103529. Epub 2020 Jun 12. Aging (Albany NY). 2020. PMID: 32530820 Free PMC article. No abstract available.
Synectin-dependent gene expression in endothelial cells.
Lanahan AA, Chittenden TW, Mulvihill E, Smith K, Schwartz S, Simons M. Lanahan AA, et al. Among authors: simons m. Physiol Genomics. 2006 Nov 27;27(3):380-90. doi: 10.1152/physiolgenomics.00145.2006. Epub 2006 Aug 29. Physiol Genomics. 2006. PMID: 16940428
Synectin (GIPC1), a receptor scaffold protein, has been isolated by our laboratory as a syndecan-4 cytoplasmic domain binding partner that regulates important aspects of cell motility (Gao Y, Li M, Chen W, Simons M. J Cell Physiol 184: 373-379, 2000; Tkachenk …
Synectin (GIPC1), a receptor scaffold protein, has been isolated by our laboratory as a syndecan-4 cytoplasmic domain binding partner that r …
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis.
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz MA, Pober JS, Chittenden TW, Tellides G, Simons M. Chen PY, et al. Among authors: simons m. Nat Metab. 2019 Sep;1(9):912-926. doi: 10.1038/s42255-019-0102-3. Epub 2019 Aug 26. Nat Metab. 2019. PMID: 31572976 Free PMC article.
Chronic mTOR activation induces a degradative smooth muscle cell phenotype.
Li G, Wang M, Caulk AW, Cilfone NA, Gujja S, Qin L, Chen PY, Chen Z, Yousef S, Jiao Y, He C, Jiang B, Korneva A, Bersi MR, Wang G, Liu X, Mehta S, Geirsson A, Gulcher JR, Chittenden TW, Simons M, Humphrey JD, Tellides G. Li G, et al. Among authors: simons m. J Clin Invest. 2020 Mar 2;130(3):1233-1251. doi: 10.1172/JCI131048. J Clin Invest. 2020. PMID: 32039915 Free PMC article.
1,482 results