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Multiple endpoint in vitro toxicity assessment of a prototype heated tobacco product indicates substantially reduced effects compared to those of combustible cigarette.
Chapman F, Sticken ET, Wieczorek R, Pour SJ, Dethloff O, Budde J, Rudd K, Mason E, Czekala L, Yu F, Simms L, Nahde T, O'Connell G, Stevenson M. Chapman F, et al. Among authors: simms l. Toxicol In Vitro. 2023 Feb;86:105510. doi: 10.1016/j.tiv.2022.105510. Epub 2022 Nov 11. Toxicol In Vitro. 2023. PMID: 36372310 Free article.
Assessment of priority tobacco additives per the requirements of the EU Tobacco Products Directive (2014/40/EU): Part 1: Background, approach, and summary of findings.
Simms L, Clarke A, Paschke T, Manson A, Murphy J, Stabbert R, Esposito M, Ghosh D, Roemer E, Martinez J, Freiesleben J, Kim HK, Lindegaard T, Scharfe M, Vincze I, Vlachos P, Wigotzki D, Pollner G, Lutz R. Simms L, et al. Regul Toxicol Pharmacol. 2019 Jun;104:84-97. doi: 10.1016/j.yrtph.2019.02.011. Epub 2019 Feb 21. Regul Toxicol Pharmacol. 2019. PMID: 30797887 Free article.
The in vitro ToxTracker and Aneugen Clastogen Evaluation extension assay as a tool in the assessment of relative genotoxic potential of e-liquids and their aerosols.
Czekala L, Chapman F, Simms L, Rudd K, Trelles Sticken E, Wieczorek R, Bode LM, Pani J, Moelijker N, Derr R, Brandsma I, Hendriks G, Stevenson M, Walele T. Czekala L, et al. Among authors: simms l. Mutagenesis. 2021 May 31;36(2):129-142. doi: 10.1093/mutage/geaa033. Mutagenesis. 2021. PMID: 33769537 Free PMC article.
The use of human induced pluripotent stem cells to screen for developmental toxicity potential indicates reduced potential for non-combusted products, when compared to cigarettes.
Simms L, Rudd K, Palmer J, Czekala L, Yu F, Chapman F, Trelles Sticken E, Wieczorek R, Bode LM, Stevenson M, Walele T. Simms L, et al. Curr Res Toxicol. 2020 Nov 15;1:161-173. doi: 10.1016/j.crtox.2020.11.001. eCollection 2020 Jun 10. Curr Res Toxicol. 2020. PMID: 34345845 Free PMC article.
311 results