Simms L - Search Results

1

Use of a rapid human primary cell-based disease screening model, to compare next generation products to combustible cigarettes.

Simms L, Mason E, Berg EL, Yu F, Rudd K, Czekala L, Trelles Sticken E, Brinster O, Wieczorek R, Stevenson M, Walele T. Simms L, et al. Curr Res Toxicol. 2021 Aug 17;2:309-321. doi: 10.1016/j.crtox.2021.08.003. eCollection 2021. Curr Res Toxicol. 2021. PMID: 34485931 Free PMC article.

2

The use of Genomic Allergen Rapid Detection (GARD) assays to predict the respiratory and skin sensitising potential of e-liquids.

Stevenson M, Czekala L, Simms L, Tschierske N, Larne O, Walele T. Stevenson M, et al. Among authors: simms l. Regul Toxicol Pharmacol. 2019 Apr;103:158-165. doi: 10.1016/j.yrtph.2019.01.001. Epub 2019 Jan 7. Regul Toxicol Pharmacol. 2019. PMID: 30629970 Free article.

3

Toxicological comparison of cigarette smoke and e-cigarette aerosol using a 3D in vitro human respiratory model.

Czekala L, Simms L, Stevenson M, Tschierske N, Maione AG, Walele T. Czekala L, et al. Among authors: simms l. Regul Toxicol Pharmacol. 2019 Apr;103:314-324. doi: 10.1016/j.yrtph.2019.01.036. Epub 2019 Feb 2. Regul Toxicol Pharmacol. 2019. PMID: 30721718 Free article.

4

High Content Screening in NHBE cells shows significantly reduced biological activity of flavoured e-liquids, when compared to cigarette smoke condensate.

Czekala L, Simms L, Stevenson M, Trelles-Sticken E, Walker P, Walele T. Czekala L, et al. Among authors: simms l. Toxicol In Vitro. 2019 Aug;58:86-96. doi: 10.1016/j.tiv.2019.03.018. Epub 2019 Mar 14. Toxicol In Vitro. 2019. PMID: 30880017 Free article.

5

A comparative in vitro toxicity assessment of electronic vaping product e-liquids and aerosols with tobacco cigarette smoke.

Wieczorek R, Phillips G, Czekala L, Trelles Sticken E, O'Connell G, Simms L, Rudd K, Stevenson M, Walele T. Wieczorek R, et al. Among authors: simms l. Toxicol In Vitro. 2020 Aug;66:104866. doi: 10.1016/j.tiv.2020.104866. Epub 2020 Apr 27. Toxicol In Vitro. 2020. PMID: 32353510 Free article.

6

The in vitro ToxTracker and Aneugen Clastogen Evaluation extension assay as a tool in the assessment of relative genotoxic potential of e-liquids and their aerosols.

Czekala L, Chapman F, Simms L, Rudd K, Trelles Sticken E, Wieczorek R, Bode LM, Pani J, Moelijker N, Derr R, Brandsma I, Hendriks G, Stevenson M, Walele T. Czekala L, et al. Among authors: simms l. Mutagenesis. 2021 May 31;36(2):129-142. doi: 10.1093/mutage/geaa033. Mutagenesis. 2021. PMID: 33769537 Free PMC article.

7

The use of human induced pluripotent stem cells to screen for developmental toxicity potential indicates reduced potential for non-combusted products, when compared to cigarettes.

Simms L, Rudd K, Palmer J, Czekala L, Yu F, Chapman F, Trelles Sticken E, Wieczorek R, Bode LM, Stevenson M, Walele T. Simms L, et al. Curr Res Toxicol. 2020 Nov 15;1:161-173. doi: 10.1016/j.crtox.2020.11.001. eCollection 2020 Jun 10. Curr Res Toxicol. 2020. PMID: 34345845 Free PMC article.

8

Multi-endpoint analysis of human 3D airway epithelium following repeated exposure to whole electronic vapor product aerosol or cigarette smoke.

Czekala L, Wieczorek R, Simms L, Yu F, Budde J, Trelles Sticken E, Rudd K, Verron T, Brinster O, Stevenson M, Walele T. Czekala L, et al. Among authors: simms l. Curr Res Toxicol. 2021 Feb 20;2:99-115. doi: 10.1016/j.crtox.2021.02.004. eCollection 2021. Curr Res Toxicol. 2021. PMID: 34345855 Free PMC article.

9

Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Predict the Cardiotoxicity Potential of Next Generation Nicotine Products.

Simms L, Yu F, Palmer J, Rudd K, Sticken ET, Wieczorek R, Chapman F, Czekala L, Stevenson M, O'Connell G. Simms L, et al. Front Toxicol. 2022 Feb 16;4:747508. doi: 10.3389/ftox.2022.747508. eCollection 2022. Front Toxicol. 2022. PMID: 35295225 Free PMC article.

10

Key challenges for in vitro testing of tobacco products for regulatory applications: Recommendations for dosimetry.

Miller-Holt J, Behrsing H, Crooks I, Curren R, Demir K, Gafner J, Gillman G, Hollings M, Leverette R, Oldham M, Simms L, Stankowski LF Jr, Thorne D, Wieczorek R, Moore MM. Miller-Holt J, et al. Among authors: simms l. Drug Test Anal. 2023 Oct;15(10):1175-1188. doi: 10.1002/dta.3344. Epub 2022 Aug 16. Drug Test Anal. 2023. PMID: 35830202 Free PMC article.

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