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NF-κB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling.
Lacher SM, Thurm C, Distler U, Mohebiany AN, Israel N, Kitic M, Ebering A, Tang Y, Klein M, Wabnitz GH, Wanke F, Samstag Y, Bopp T, Kurschus FC, Simeoni L, Tenzer S, Waisman A. Lacher SM, et al. Among authors: simeoni l. J Autoimmun. 2018 Nov;94:110-121. doi: 10.1016/j.jaut.2018.07.017. Epub 2018 Jul 29. J Autoimmun. 2018. PMID: 30061013
The transmembrane adaptor protein SIT inhibits TCR-mediated signaling.
Arndt B, Krieger T, Kalinski T, Thielitz A, Reinhold D, Roessner A, Schraven B, Simeoni L. Arndt B, et al. Among authors: simeoni l. PLoS One. 2011;6(9):e23761. doi: 10.1371/journal.pone.0023761. Epub 2011 Sep 21. PLoS One. 2011. PMID: 21957439 Free PMC article.
Sos1 regulates sustained TCR-mediated Erk activation.
Poltorak M, Meinert I, Stone JC, Schraven B, Simeoni L. Poltorak M, et al. Among authors: simeoni l. Eur J Immunol. 2014 May;44(5):1535-40. doi: 10.1002/eji.201344046. Epub 2014 Feb 20. Eur J Immunol. 2014. PMID: 24497027 Free article. Clinical Trial.
101 results