Simaan M - Search Results

1

Cross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration.

Alonso N, Fernandez N, Notcovich C, Monczor F, Simaan M, Baldi A, Gutkind JS, Davio C, Shayo C. Alonso N, et al. Among authors: simaan m. Mol Pharmacol. 2013 May;83(5):1087-98. doi: 10.1124/mol.112.083394. Epub 2013 Mar 5. Mol Pharmacol. 2013. PMID: 23462507 Free PMC article.

2

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.

Mikelis CM, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, Masedunskas A, Weigert R, Chavakis T, Adams RH, Offermanns S, Mochizuki N, Zheng Y, Gutkind JS. Mikelis CM, et al. Among authors: simaan m. Nat Commun. 2015 Apr 10;6:6725. doi: 10.1038/ncomms7725. Nat Commun. 2015. PMID: 25857352 Free PMC article.

3

Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.

Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor SS, Molinolo AA, Gutkind JS. Iglesias-Bartolome R, et al. Among authors: simaan m. Nat Cell Biol. 2015 Jun;17(6):793-803. doi: 10.1038/ncb3164. Epub 2015 May 11. Nat Cell Biol. 2015. PMID: 25961504 Free PMC article.

4

A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells.

Yagi H, Tan W, Dillenburg-Pilla P, Armando S, Amornphimoltham P, Simaan M, Weigert R, Molinolo AA, Bouvier M, Gutkind JS. Yagi H, et al. Among authors: simaan m. Sci Signal. 2011 Sep 20;4(191):ra60. doi: 10.1126/scisignal.2002221. Sci Signal. 2011. PMID: 21934106 Free PMC article.

5

Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation.

Prickett TD, Zerlanko BJ, Hill VK, Gartner JJ, Qutob N, Jiang J, Simaan M, Wunderlich J, Gutkind JS, Rosenberg SA, Samuels Y. Prickett TD, et al. Among authors: simaan m. J Invest Dermatol. 2014 Sep;134(9):2390-2398. doi: 10.1038/jid.2014.190. Epub 2014 Apr 16. J Invest Dermatol. 2014. PMID: 24739903 Free PMC article.

6

PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.

Mikelis CM, Palmby TR, Simaan M, Li W, Szabo R, Lyons R, Martin D, Yagi H, Fukuhara S, Chikumi H, Galisteo R, Mukouyama YS, Bugge TH, Gutkind JS. Mikelis CM, et al. Among authors: simaan m. J Biol Chem. 2013 Apr 26;288(17):12232-43. doi: 10.1074/jbc.M112.428599. Epub 2013 Mar 6. J Biol Chem. 2013. PMID: 23467409 Free PMC article.

7

Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling.

House CD, Wang BD, Ceniccola K, Williams R, Simaan M, Olender J, Patel V, Baptista-Hon DT, Annunziata CM, Gutkind JS, Hales TG, Lee NH. House CD, et al. Among authors: simaan m. Sci Rep. 2015 Jun 22;5:11541. doi: 10.1038/srep11541. Sci Rep. 2015. PMID: 26096612 Free PMC article.

8

Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex.

Fessart D, Simaan M, Zimmerman B, Comeau J, Hamdan FF, Wiseman PW, Bouvier M, Laporte SA. Fessart D, et al. Among authors: simaan m. J Cell Sci. 2007 May 15;120(Pt 10):1723-32. doi: 10.1242/jcs.03444. Epub 2007 Apr 24. J Cell Sci. 2007. PMID: 17456551

9

Differential regulation of endosomal GPCR/β-arrestin complexes and trafficking by MAPK.

Khoury E, Nikolajev L, Simaan M, Namkung Y, Laporte SA. Khoury E, et al. Among authors: simaan m. J Biol Chem. 2014 Aug 22;289(34):23302-17. doi: 10.1074/jbc.M114.568147. Epub 2014 Jul 11. J Biol Chem. 2014. PMID: 25016018 Free PMC article.

10

c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin- mediated internalization.

Fessart D, Simaan M, Laporte SA. Fessart D, et al. Among authors: simaan m. Mol Endocrinol. 2005 Feb;19(2):491-503. doi: 10.1210/me.2004-0246. Epub 2004 Oct 21. Mol Endocrinol. 2005. PMID: 15498833

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