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Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase.
Giancotti G, Nannetti G, Padalino G, Landini M, Santos-Ferreira N, Van Dycke J, Naccarato V, Patel U, Silvestri R, Neyts J, Gozalbo-Rovira R, Rodríguez-Díaz J, Rocha-Pereira J, Brancale A, Ferla S, Bassetto M. Giancotti G, et al. Among authors: silvestri r. Viruses. 2022 Dec 27;15(1):74. doi: 10.3390/v15010074. Viruses. 2022. PMID: 36680114 Free PMC article.
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
Piscitelli F, Coluccia A, Brancale A, La Regina G, Sansone A, Giordano C, Balzarini J, Maga G, Zanoli S, Samuele A, Cirilli R, La Torre F, Lavecchia A, Novellino E, Silvestri R. Piscitelli F, et al. Among authors: silvestri r. J Med Chem. 2009 Apr 9;52(7):1922-34. doi: 10.1021/jm801470b. J Med Chem. 2009. PMID: 19281225
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors.
La Regina G, Coluccia A, Brancale A, Piscitelli F, Famiglini V, Cosconati S, Maga G, Samuele A, Gonzalez E, Clotet B, Schols D, Esté JA, Novellino E, Silvestri R. La Regina G, et al. Among authors: silvestri r. J Med Chem. 2012 Jul 26;55(14):6634-8. doi: 10.1021/jm300477h. Epub 2012 Jul 6. J Med Chem. 2012. PMID: 22712652
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus.
Bassetto M, De Burghgraeve T, Delang L, Massarotti A, Coluccia A, Zonta N, Gatti V, Colombano G, Sorba G, Silvestri R, Tron GC, Neyts J, Leyssen P, Brancale A. Bassetto M, et al. Among authors: silvestri r. Antiviral Res. 2013 Apr;98(1):12-8. doi: 10.1016/j.antiviral.2013.01.002. Epub 2013 Feb 1. Antiviral Res. 2013. PMID: 23380636 Free article.
De novo computer-aided design of novel antiviral agents.
Massarotti A, Coluccia A, Sorba G, Silvestri R, Brancale A. Massarotti A, et al. Among authors: silvestri r. Drug Discov Today Technol. 2012 Autumn;9(3):e213-8. doi: 10.1016/j.ddtec.2011.11.008. Drug Discov Today Technol. 2012. PMID: 24990574
319 results