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Oxidative stress and TGF-β1 induction by metformin in MCF-7 and MDA-MB-231 human breast cancer cells are accompanied with the downregulation of genes related to cell proliferation, invasion and metastasis.
Marinello PC, Panis C, Silva TNX, Binato R, Abdelhay E, Rodrigues JA, L Mencalha A, Lopes NMD, Borges FH, Luiz RC, Cecchini R, Cecchini AL. Marinello PC, et al. Among authors: silva tnx. Pathol Res Pract. 2020 Oct;216(10):153135. doi: 10.1016/j.prp.2020.153135. Epub 2020 Jul 26. Pathol Res Pract. 2020. PMID: 32853957
Mechanism of metformin action in MCF-7 and MDA-MB-231 human breast cancer cells involves oxidative stress generation, DNA damage, and transforming growth factor β1 induction.
Marinello PC, da Silva TN, Panis C, Neves AF, Machado KL, Borges FH, Guarnier FA, Bernardes SS, de-Freitas-Junior JC, Morgado-Díaz JA, Luiz RC, Cecchini R, Cecchini AL. Marinello PC, et al. Tumour Biol. 2016 Apr;37(4):5337-46. doi: 10.1007/s13277-015-4395-x. Epub 2015 Nov 11. Tumour Biol. 2016. PMID: 26561471