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Trinucleotide mRNA Cap Analogue N6-Benzylated at the Site of Posttranscriptional m6Am Mark Facilitates mRNA Purification and Confers Superior Translational Properties In Vitro and In Vivo.
Warminski M, Trepkowska E, Smietanski M, Sikorski PJ, Baranowski MR, Bednarczyk M, Kedzierska H, Majewski B, Mamot A, Papiernik D, Popielec A, Serwa RA, Shimanski BA, Sklepkiewicz P, Sklucka M, Sokolowska O, Spiewla T, Toczydlowska-Socha D, Warminska Z, Wolosewicz K, Zuberek J, Mugridge JS, Nowis D, Golab J, Jemielity J, Kowalska J. Warminski M, et al. Among authors: sikorski pj. J Am Chem Soc. 2024 Mar 27;146(12):8149-8163. doi: 10.1021/jacs.3c12629. Epub 2024 Mar 5. J Am Chem Soc. 2024. PMID: 38442005 Free PMC article.
Applications of Phosphate Modification and Labeling to Study (m)RNA Caps.
Warminski M, Sikorski PJ, Kowalska J, Jemielity J. Warminski M, et al. Among authors: sikorski pj. Top Curr Chem (Cham). 2017 Feb;375(1):16. doi: 10.1007/s41061-017-0106-y. Epub 2017 Jan 23. Top Curr Chem (Cham). 2017. PMID: 28116583 Free PMC article. Review.
mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation.
Rydzik AM, Warminski M, Sikorski PJ, Baranowski MR, Walczak S, Kowalska J, Zuberek J, Lukaszewicz M, Nowak E, W Claridge TD, Darzynkiewicz E, Nowotny M, Jemielity J. Rydzik AM, et al. Among authors: sikorski pj. Nucleic Acids Res. 2017 Sep 6;45(15):8661-8675. doi: 10.1093/nar/gkx569. Nucleic Acids Res. 2017. PMID: 28666355 Free PMC article.
Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect.
Warminski M, Kowalska J, Nowak E, Kubacka D, Tibble R, Kasprzyk R, Sikorski PJ, Gross JD, Nowotny M, Jemielity J. Warminski M, et al. Among authors: sikorski pj. ACS Chem Biol. 2021 Feb 19;16(2):334-343. doi: 10.1021/acschembio.0c00864. Epub 2021 Jan 13. ACS Chem Biol. 2021. PMID: 33439620 Free PMC article.
27 results